{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T21:29:22Z","timestamp":1786656562792,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010inflammatory hyperpigmentation (PIH) is among the most burdensome sequelae of inflammatory dermatoses in skin of color (SOC), and reduction of visible pigmentation represents the primary clinical outcome of interest. Tinted sunscreens containing iron oxides and\/or pigmentary titanium dioxide are currently the best\u2010evidenced strategy for preventing visible light\u2013driven PIH in SOC. However, cosmetic unacceptability\u2014including white cast, poor shade match, and texture incompatibility with acne\u2010prone skin\u2014significantly limits real\u2010world adherence. This concept paper proposes a clinical reframing: when pigment\u2010based visible light filters are not tolerated, pigmentation reduction may be achievable through proactive topical actives with direct anti\u2010pigmentation activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This commentary synthesizes the mechanistic and clinical literature on high\u2010energy visible light (HEVL)\u2013driven pigmentation in SOC, with particular focus on the opsin\u20103\u2013MITF\u2013melanogenesis axis and topical actives with demonstrated anti\u2010pigmentation activity against HEVL\u2010induced melanogenesis. Evidence is presented to support a proposed clinical reframing and pragmatic algorithm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HEVL activates opsin\u20103 on melanocytes, upregulating MITF and promoting formation of stable, autophagy\u2010resistant melanosomes\u2014a mechanism distinct from UVA\u2010driven photooxidation and particularly relevant in darker phototypes. Four prototypical actives with direct clinical or preclinical evidence against HEVL\u2010induced pigmentation are reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pigmentation reduction\u2014rather than the mechanism by which it is achieved\u2014should be recognized as the primary clinical endpoint in photoprotection for PIH in SOC. When pigment\u2010based visible light filters containing iron oxides and\/or pigmentary titanium dioxide are cosmetically unacceptable, a strategy combining broad\u2010spectrum UVA1 photoprotection with a topical active with anti\u2010pigmentation activity represents a rational, evidence\u2010informed alternative that keeps the clinical goal firmly in focus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.70112","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T17:31:11Z","timestamp":1785000671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Tint: Active Ingredient Strategies for Post\u2010Inflammatory Hyperpigmentation due to Visible Light in Skin of Color"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2701-4632","authenticated-orcid":false,"given":"Willem Izak","family":"Visser","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine and Health Sciences Stellenbosch University  Cape Town South Africa"},{"name":"Tygerberg Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-5515","authenticated-orcid":false,"given":"Husna","family":"Moola","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine and Health Sciences Stellenbosch University  Cape Town South Africa"},{"name":"Tygerberg Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9881-1631","authenticated-orcid":false,"given":"Susanna","family":"Kannenberg","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine and Health Sciences Stellenbosch University  Cape Town South Africa"},{"name":"Tygerberg Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8204-8478","authenticated-orcid":false,"given":"Bianca","family":"Tod","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine and Health Sciences Stellenbosch University  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1576-1115","authenticated-orcid":false,"given":"Henry W.","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Photobiology and Photomedicine, Department of Dermatology Henry Ford Health  Detroit Michigan USA"},{"name":"Department of Dermatology College of Human Medicine, Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"issue":"7","key":"e_1_2_14_2_1","article-title":"Racial Differences in Clinical Characteristics, Perceptions and Behaviors, and Psychosocial Impact of Adult Female Acne","volume":"7","author":"Callender V. 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IMCAS. Loreal \u201d(2025) https:\/\/mail.google.com\/mail\/u\/0\/#search\/visser\/FMfcgzQgLPLKhfWFpKVJpLthPcGqfnnH?projector=1&messagePartId=0.1."},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/S43630\u2010025\u201000844\u20102\/FIGURES\/3"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/S13555\u2010025\u201001649\u2010Y\/TABLES\/7"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS21030988"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.5935\/scd1984\u20108773.201911408"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/ICS.12637"},{"key":"e_1_2_14_35_1","unstructured":"W. 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