{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:12:01Z","timestamp":1790604721225,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Purpose<\/jats:title>\n                    <jats:p>Visible light (VL), and particularly high\u2010energy visible light (HEVL), reaching Earth's surface has emerged as a relevant contributor to skin damage. VL has been implicated in oxidative stress, inflammation, pigmentation disorders, and photoaging, especially in individuals with darker skin phototypes. As conventional sunscreens offer limited protection in the visible spectrum, increasing attention has been directed toward complementary photoprotective strategies, including the use of natural compounds with antioxidant and anti\u2010inflammatory properties. This systematic review aims to evaluate and synthesize the available preclinical and clinical evidence on the photoprotective effects of natural compounds against VL\u2010induced skin damage, emphasizing their mechanisms of action, efficacy, and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was performed to identify studies reporting validated objective outcomes, including colorimetric parameters, diffuse reflectance spectroscopy, or clinical grading scales. Eligible studies were included, qualitatively synthesized, and risk of bias was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Preclinical studies demonstrated that natural compounds mitigated VL\u2010induced oxidative stress, inflammation, and pigmentation\u2010related pathways. Clinical studies showed that formulations containing natural compounds improved VL\u2010induced erythema and pigmentation outcomes. However, considerable heterogeneity was observed in irradiation protocols, outcome measures, and study designs, precluding quantitative meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, available evidence supports a protective role for selected natural compounds against VL\u2010induced skin damage, particularly through antioxidant and anti\u2010inflammatory mechanisms, with the strongest clinical evidence focusing on natural sources of polyphenols. Nevertheless, this review highlights the need for standardized phototesting protocols and well\u2010designed clinical trials. Future research should focus on comparative efficacy, long\u2010term safety, and integration of natural compounds into combined photoprotection strategies tailored to different skin phototypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.70113","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T07:30:32Z","timestamp":1786001432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural Agents for Preventing Skin Damage Induced by Visible Light: A Systematic Review of Preclinical and Clinical Evidence"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1529-7674","authenticated-orcid":false,"given":"Azahara","family":"Rodr\u00edguez\u2010Luna","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences Universidad Loyola Andaluc\u00eda  Sevilla Spain"},{"name":"Department of Experimental Dermatology and Skin Biology Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria, IRYCIS  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7711-2145","authenticated-orcid":false,"given":"Alicia","family":"Zamarr\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences Autonoma University of Madrid (UAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2621-2098","authenticated-orcid":false,"given":"Cristina","family":"Garc\u00eda\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Universidad de Sevilla  Sevilla Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2525-4069","authenticated-orcid":false,"given":"Juan\u2010Carlos","family":"Hern\u00e1ndez\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Virgen del Roc\u00edo  Sevilla Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1576-1115","authenticated-orcid":false,"given":"Henry W.","family":"Lim","sequence":"additional","affiliation":[{"name":"The Henry W. Lim Division of Photobiology and Photomedicine, Department of Dermatology Henry Ford Health  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9282-4784","authenticated-orcid":false,"given":"Salvador","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties Alcal\u00e1 de Henares University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.02.048"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11081484"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2021.1950767"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.12.047"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.14117"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2024.07.034"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17242"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19677"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256022"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.079"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12967"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010009\u20101001\u20103"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00392"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13525"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed\u20102020\u2010209567"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12637"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475417724440"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12937"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12785"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.01.044"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082250"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030400"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27584"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.12.028"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15354"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2014.2461"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12523"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics8010023"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030988"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14061217"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3839\/jabc.2023.016"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13765\u2010023\u201000767\u20105"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14202"},{"issue":"12","key":"e_1_2_9_37_1","first-page":"1198","article-title":"Oral Polypodium Leucotomos Extract and Its Impact on Visible Light\u2010Induced Pigmentation in Human Subjects","volume":"18","author":"Mohammad T. 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