{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:12:07Z","timestamp":1790604727552,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The transdermal permeation of UV filters has long been a concern among consumers and researchers. Among them, the permeation of small\u2010molecule UV filters such as homosalate (HMS) (molecular weight\u2009&lt;\u2009500\u2009Da) and the regulatory effects of formulation components on its permeation have not been fully investigated. Furthermore, sunscreen formulations containing skin brightening agents have become increasingly prevalent in recent years. Thus, verifying how to adjust formulation components to reduce UV filter permeation while not influencing the permeation of active ingredients such as the skin\u2010brightening agent niacinamide is worthy of research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study investigated the skin permeation of formulations containing HMS using an improved confocal Raman spectroscopy method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the tested UV filters, HMS exhibited the highest permeation, with a relative permeability rate of 4.2% and a maximum permeation depth of 60\u2009\u03bcm. Subsequently, adjusting the proportion of components in the formulation indicated that thickeners (Carbomer and Acrylates\/C10\u201030 Alkyl Acrylate Crosspolymer) and emulsifiers (PEG (Polyethylene Glycol)\u2010100 Stearate\/Glyceryl Stearate) could reduce the permeation of HMS, while the film\u2010formers (VP (Vinylpyrrolidone)\/Eicosene) had no impact on HMS permeation. Based on these findings, a real\u2010life sunscreen formulation was designed and verified to reduce HMS permeation while ensuring effective skin permeation of niacinamide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The permeation of different single UV filters by confocal Raman spectroscopy suggested that HMS exhibited the deepest permeation. Subsequently, by designing a series of distinct formulations, we identified the formulation components that influence the permeation of HMS. Based on the study findings, a practical formulation was designed that not only minimizes the permeation of the UV filter (HMS) but also does not inhibit the permeation of the skin\u2010brightening agent. This study may serve as a reference for subsequent investigations into the permeation of UV filters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.70116","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:55:38Z","timestamp":1786654538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Efficacy of Sunscreen Formulas in Reducing\n                    <scp>UV<\/scp>\n                    Filter Permeation Into the Stratum Corneum via In\u00a0Vivo Confocal Raman Spectroscopy: Insights and Applications for Practical Suncare Product Design"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5655-3287","authenticated-orcid":false,"given":"Tao","family":"Zhang","sequence":"first","affiliation":[{"name":"Better Way (Shanghai) Cosmetics co. Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangwei","family":"Lu","sequence":"additional","affiliation":[{"name":"Hangzhou Shiguang Xinya Biotechnology co., Ltd.  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangqian","family":"Ning","sequence":"additional","affiliation":[{"name":"Better Way (Shanghai) Cosmetics co. Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Better Way (Shanghai) Cosmetics co. Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyang","family":"Li","sequence":"additional","affiliation":[{"name":"Better Way (Shanghai) Cosmetics co. Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Better Way (Shanghai) Cosmetics co. Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Better Way (Shanghai) Cosmetics co. Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0042-8666","authenticated-orcid":false,"given":"Yuankun","family":"Liu","sequence":"additional","affiliation":[{"name":"Hangzhou Shiguang Xinya Biotechnology co., Ltd.  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayue","family":"Chen","sequence":"additional","affiliation":[{"name":"Hangzhou Shiguang Xinya Biotechnology co., Ltd.  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.2344"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.02.062"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2013.861376"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2023.140271"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010024\u201003704\u20107"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.120013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2023.122868"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10812\u2010018\u20100688\u20103"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249\u2010017\u20100852\u20108"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5c04694"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13069"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12523"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249\u2010018\u20101143\u20108"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5AN02373D"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optcom.2022.127977"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0AN02480E"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.70166"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101747.2001.01398.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20102494.2008.00417.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20102494.2008.00430_1.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101747.2003.12606.x"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.70116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/phpp.70116","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.70116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:52:59Z","timestamp":1790603579000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.70116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/phpp.70116"],"URL":"https:\/\/doi.org\/10.1111\/phpp.70116","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"2025-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70116"}}