{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:11:57Z","timestamp":1790604717855,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100024738","name":"Chulabhorn International College of Medicine, Thammasat University","doi-asserted-by":"publisher","award":["B1\/2569"],"award-info":[{"award-number":["B1\/2569"]}],"id":[{"id":"10.13039\/501100024738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Melasma is a common acquired pigmentary disorder that predominantly affects women with darker skin types and substantially impairs quality of life. Current treatments are limited by variable efficacy, adverse effects, and frequent recurrence. Platelet\u2010rich plasma (PRP) has emerged as a potential regenerative treatment through growth\u2010factor\u2013mediated modulation of melanogenesis. Photothermal activation, which combines photobiomodulation with controlled hypothermic conditioning, has been hypothesized to promote a more sustained growth\u2010factor release than conventional PRP. This study compared the efficacy and safety of photothermal\u2010activated PRP (PT\u2010PRP) and conventional PRP (C\u2010PRP) for melasma treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This split\u2010face, double\u2010blind, randomized controlled trial included 26 women with epidermal or mixed\u2010type melasma. Each participant received three monthly sessions of intradermal PRP, with PT\u2010PRP and C\u2010PRP injected into opposite facial sides. Outcomes were assessed at weeks 0, 4, 8, and 12 using the modified Melasma Area and Severity Index (mMASI), Mexameter melanin and erythema indices, patient satisfaction, overall improvement, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both treatments significantly reduced mMASI by week 12, with no significant between\u2010group differences at any time point. C\u2010PRP showed significant mMASI improvement from week 4, whereas PT\u2010PRP reached significance from week 8. For the melanin index, PT\u2010PRP produced a significant within\u2010group reduction at week 12, while C\u2010PRP did not. At week 12, PT\u2010PRP showed a significantly lower melanin index than C\u2010PRP. Mild injection\u2010site bruising was the only adverse event.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PT\u2010PRP and C\u2010PRP produced comparable clinical improvement, but PT\u2010PRP achieved greater objective melanin reduction at week 12. PT\u2010PRP may represent a safe alternative treatment for melasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Thai Clinical Trials Registry: TCTR20260318004<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.70122","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:01:20Z","timestamp":1789239680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photothermal\u2010Activated Platelet\u2010Rich Plasma Versus Conventional Platelet\u2010Rich Plasma for Melasma: A Split\u2010Face, Double\u2010Blind Randomized Controlled Trial"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1298-2584","authenticated-orcid":false,"given":"Rueangrit","family":"Siriphanit","sequence":"first","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University (Rangsit Campus)  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattachar","family":"Ranoppawan","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University (Rangsit Campus)  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9330-7032","authenticated-orcid":false,"given":"Sasin","family":"Charoensuksira","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University (Rangsit Campus)  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5070-5477","authenticated-orcid":false,"given":"Wilai","family":"Thanasarnaksorn","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University (Rangsit Campus)  Pathum Thani Thailand"},{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"},{"name":"Samitivej Sukhumvit Hospital Bangkok Dusit Medical Services PLC  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3432-7090","authenticated-orcid":false,"given":"Atchima","family":"Suwanchinda","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University (Rangsit Campus)  Pathum Thani Thailand"},{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7490-5134","authenticated-orcid":false,"given":"Jitlada","family":"Meephansan","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University (Rangsit Campus)  Pathum Thani Thailand"},{"name":"Samitivej Sukhumvit Hospital Bangkok Dusit Medical Services PLC  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20143063"},{"key":"e_1_2_13_3_1","volume-title":"Fitzpatrick's Dermatology 9th Edition","author":"Sewon Kang M. 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