{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:26:54Z","timestamp":1781594814350,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T00:00:00Z","timestamp":1357689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Cystic echinococcosis caused by <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>chinococcus granulosus<\/jats:italic> remains an important and neglected issue in public health. The study of the likely efficacy of the currently available <jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>95 vaccine against other genotypes of the parasite is important to improve the vaccine as a potential tool to be used in control programmes. The recombinant vaccine <jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>95\u20101<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>1 was developed based on the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>1 genotype of <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>.\u00a0granulosus<\/jats:italic>. Characterization of the <jats:italic>eg95<\/jats:italic> gene family in the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>6 genotype by genomic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> cloning previously produced the first unequivocal information about the composition of the gene family in a different genotype. The information was used in this study to predict and express two <jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>95\u2010related proteins from the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>6 genotype as recombinants, for assessment of their capacity to bind antibodies raised in sheep vaccinated with the <jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>95\u20101<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>1 vaccine. The proteins (<jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>95\u20101<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>6 and <jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>95\u20105<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>6) from the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>6 genotype of <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>.\u00a0granulosus<\/jats:italic> were unable to bind all the antibodies raised by sheep vaccinated with <jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>95\u20101<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>1. Differences in the amino acid sequence of <jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>95\u2010related proteins from <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>6 and likely the differences in the encoded <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> domain may be responsible for changes in the conformation of these epitopes.<\/jats:p>","DOI":"10.1111\/pim.12009","type":"journal-article","created":{"date-parts":[[2012,9,26]],"date-time":"2012-09-26T13:36:21Z","timestamp":1348666581000},"page":"99-102","source":"Crossref","is-referenced-by-count":37,"title":["Antigenic differences between the <scp>EG<\/scp>95\u2010related proteins from <i><scp>E<\/scp>chinococcus granulosus <\/i><scp>G<\/scp>1 and <scp>G<\/scp>6 genotypes<i>:<\/i> implications for vaccination"],"prefix":"10.1111","volume":"35","author":[{"given":"C. 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