{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:50:34Z","timestamp":1789984234926,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2013,2,5]],"date-time":"2013-02-05T00:00:00Z","timestamp":1360022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A new glyco\u2010derivative compound (<jats:styled-content style=\"fixed-case\">OCTAM<\/jats:styled-content>) was developed and labelled with isotope to form <jats:sup>188<\/jats:sup>Re\u2010<jats:styled-content style=\"fixed-case\">OCTAM<\/jats:styled-content> as a candidate nuclear medicine imaging agent for testing the liver function. We evaluated the potential of isotope\u2010labelled <jats:styled-content style=\"fixed-case\">OCTAM<\/jats:styled-content> for estimating the remnant liver function <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> schistosoma\u2010infected mice. The affinity of <jats:styled-content style=\"fixed-case\">OCTAM<\/jats:styled-content> to liver asialoglycoprotein receptors (<jats:styled-content style=\"fixed-case\">ASGPR<\/jats:styled-content>) was assessed by competitive inhibition assay <jats:italic>in vitro<\/jats:italic>. <jats:italic>In vivo<\/jats:italic> assessments were performed to score the remnant liver function in mice at different schistosomal infection stages. <jats:styled-content style=\"fixed-case\">OCTAM<\/jats:styled-content> binds specifically to <jats:styled-content style=\"fixed-case\">ASGPR<\/jats:styled-content> and showed competitive inhibition of anti\u2010<jats:styled-content style=\"fixed-case\">ASGPR<\/jats:styled-content> antibody binding to hepatocytes, and was higher than that of other galactosyl ligands. Micro\u2010<jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> images of uninfected mice revealed strong liver uptake. Quantified serial images of mice infected for 9, 12 and 18\u00a0weeks showed delayed liver uptake, and the retention of uptake was inversely correlated with stage and grade of schistosoma infection. Pathological and biochemical analysis demonstrated that gradually accumulating liver injury caused by infection significantly influenced uptake of <jats:sup>188<\/jats:sup>Re\u2010<jats:styled-content style=\"fixed-case\">OCTAM<\/jats:styled-content>. Hepatic <jats:styled-content style=\"fixed-case\">ASGPR<\/jats:styled-content> expression diminished only in the chronic infection stage. This study demonstrated that the isotope\u2010labelled <jats:styled-content style=\"fixed-case\">OCTAM<\/jats:styled-content> could accumulate in the liver, might have potential as an imaging agent for <jats:italic>in vivo<\/jats:italic> hepatic function evaluation of schistosomiasis.<\/jats:p>","DOI":"10.1111\/pim.12022","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T10:55:31Z","timestamp":1354791331000},"page":"129-139","source":"Crossref","is-referenced-by-count":8,"title":["Evaluating the potential of a new isotope\u2010labelled glyco\u2010ligand for estimating the remnant liver function of schistosoma\u2010infected mice"],"prefix":"10.1111","volume":"35","author":[{"given":"P.\u2010C.","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Molecular Parasitology and Tropical Diseases School of Medicine, College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Center for International Tropical Medicine College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.\u2010F.","family":"Chiang","sequence":"additional","affiliation":[{"name":"Isotope Application Division Institute of Nuclear Energy Research Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Medical Biotechnology Central Taiwan University of Science and Technology Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010H.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Isotope Application Division Institute of Nuclear Energy Research Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010L.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Isotope Application Division Institute of Nuclear Energy Research Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010W.","family":"Liu","sequence":"additional","affiliation":[{"name":"Chemistry Division Institute of Nuclear Energy Research Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.\u2010H.","family":"Shen","sequence":"additional","affiliation":[{"name":"Isotope Application Division Institute of Nuclear Energy Research Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010L.","family":"Peng","sequence":"additional","affiliation":[{"name":"Isotope Application Division Institute of Nuclear Energy Research Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010K.","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Molecular Parasitology and Tropical Diseases School of Medicine, College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Center for International Tropical Medicine College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.\u2010Y.","family":"Luo","sequence":"additional","affiliation":[{"name":"Isotope Application Division Institute of Nuclear Energy Research Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2009.03.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2009.03.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.43273"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc9700796"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1995.75.3.591"},{"key":"e_1_2_6_8_1","first-page":"32","article-title":"Hepatic functional scintigraphic imaging with 99\u00a0mtechnetium galactosyl serum albumin","volume":"40","author":"Kubota Y","year":"1993","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_9_1","first-page":"321","article-title":"Characterization of the asialoglycoprotein receptor under hypoxic conditions in primary cultured rat hepatocytes","volume":"46","author":"Kwon AH","year":"2005","journal-title":"J Nucl Med"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199504000-00008"},{"key":"e_1_2_6_11_1","first-page":"1401","volume-title":"Hepatology","author":"Sugahara K","year":"2003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.2967\/jnumed.110.078360","article-title":"Quantitative assessment of hepatic function during liver regeneration in a standardized rat model","volume":"52","author":"de Graaf W","journal-title":"J Nucl Med"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1016\/S0021-9258(19)85538-2","article-title":"Human hepatic lectin. 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