{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:15:49Z","timestamp":1777421749114,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Infections with <jats:italic>Trichuris trichiura<\/jats:italic> and other trichurid nematodes have been reported to display protective effects against atopy, allergic and autoimmune diseases. The aims of the present study were to investigate the immunomodulatory properties of <jats:italic>T. trichiura<\/jats:italic> adult worm extract (Tt<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>) and its fractions (Tt<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>s) on the production of cytokines by peripheral blood mononuclear cells and to identify their proteinaceous components. Fourteen Tt<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>s were obtained by ion exchange chromatography and tested for effects on cytokine production by peripheral blood mononuclear cells. The molecular constituents of the six most active fractions were evaluated using nano\u2010<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\/mass spectrometry. The homology between <jats:italic>T. trichiura<\/jats:italic> and the related nematode <jats:italic>Trichinella spiralis<\/jats:italic> was used to identify 12 proteins in Tt<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>s. Among those identified, fructose biphosphate aldolase, a homologue of macrophage migration inhibitory factor and heat\u2010shock protein 70 may contribute to the immunomodulatory effects of Tt<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>s. The identification of such proteins could lead to the development of novel drugs for the therapy of allergic and other inflammatory diseases.<\/jats:p>","DOI":"10.1111\/pim.12025","type":"journal-article","created":{"date-parts":[[2013,2,9]],"date-time":"2013-02-09T15:08:41Z","timestamp":1360422521000},"page":"188-193","source":"Crossref","is-referenced-by-count":27,"title":["A proteomic approach to identify proteins from <i>Trichuris trichiura<\/i> extract with immunomodulatory effects"],"prefix":"10.1111","volume":"35","author":[{"given":"L. N.","family":"Santos","sequence":"first","affiliation":[{"name":"Departamento de Ci\u00eancias da Biointera\u00e7\u00e3o Instituto de Ci\u00eancias da Sa\u00fade Universidade Federal da Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B. 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