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The intensity of infection (evidenced by worm burden and liver egg burden) and liver immunopathology (number and size of liver granulomas) were significantly reduced in neonates from infected mothers (<jats:styled-content style=\"fixed-case\">I.M<\/jats:styled-content>.) compared with neonates from noninfected mothers (<jats:styled-content style=\"fixed-case\">N.M<\/jats:styled-content>.). Anti\u2010soluble worm antigen of <jats:italic>S. japonicum<\/jats:italic> (<jats:styled-content style=\"fixed-case\">SWA<\/jats:styled-content>) IgG could be detected in sera of neonates from <jats:styled-content style=\"fixed-case\">I.M<\/jats:styled-content>. (<jats:styled-content style=\"fixed-case\">N.N.\/I.M<\/jats:styled-content>.) at 1\u00a0week after delivery, remained a plateau for 2\u00a0weeks and gradually decreased until 8\u00a0weeks of age. Parasite\u2010specific IgM was not detected in sera from N.N.\/I.M. at any time after delivery. At 6\u00a0weeks after infection, the level of anti\u2010<jats:styled-content style=\"fixed-case\">SWA<\/jats:styled-content> IgG in infected neonates from <jats:styled-content style=\"fixed-case\">I.M<\/jats:styled-content>. (<jats:styled-content style=\"fixed-case\">I.N.\/I.M<\/jats:styled-content>.) was significantly higher than that of infected neonates from <jats:styled-content style=\"fixed-case\">N.M<\/jats:styled-content>. (<jats:styled-content style=\"fixed-case\">I.N.\/N.M<\/jats:styled-content>.). In addition, production of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012 and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 by cultured splenocytes from <jats:styled-content style=\"fixed-case\">I.N.\/I.M<\/jats:styled-content>. was significantly increased, while the level of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 was significantly decreased when compared to those from <jats:styled-content style=\"fixed-case\">I.N.\/N.M<\/jats:styled-content>.. These data demonstrate that congenital exposure to schistosomiasis japonica may render neonatal mice born to <jats:styled-content style=\"fixed-case\">I.M<\/jats:styled-content>. less susceptible to subsequent challenge and result in down\u2010regulation of both infection intensity and immunopathology.<\/jats:p>","DOI":"10.1111\/pim.12027","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T10:45:36Z","timestamp":1360233936000},"page":"157-163","source":"Crossref","is-referenced-by-count":8,"title":["<i>Schistosoma japonicum<\/i>: susceptibility of neonate mice born to infected and noninfected mothers following subsequent challenge"],"prefix":"10.1111","volume":"35","author":[{"given":"F.","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Parasitology Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Parasitology Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Parasitology Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Parasitology Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Parasitology Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Parasitology Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Parasitology Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Parasitology Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Parasitology Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69440-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1982.tb00377.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb.7100014"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(78)90011-1"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2008.05.027"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(74)90248-8"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119340"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/172603a0"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.4.637"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110862"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90009-4"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1017\/S0022149X9900044X","article-title":"Schistosoma japonicum infection in pregnant mice","volume":"73","author":"Bendixen M","year":"1999","journal-title":"J Helminthol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-006-0127-x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086248"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-010-2089-2"},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.4049\/jimmunol.118.2.594","article-title":"Schistosomiasis in the congenitally athymic (nude) mouse. 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