{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T17:14:28Z","timestamp":1768324468249,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Infection of the human host by schistosome parasites follows exposure of skin to free\u2010swimming cercariae and is aided by the release of excretory\/secretory (E\/S) material, which is rich in proteases and glycoconjugates. This material provides the initial stimulus to cells of the innate immune system. The study presented here is the first to examine human innate\/early immune responsiveness to cercarial E\/S in subjects from an area co\u2010endemic for <jats:italic>Schistosoma mansoni<\/jats:italic> and <jats:italic>S.\u00a0haematobium<\/jats:italic>. We report that in infected participants, stimulation of whole\u2010blood cultures with cercarial E\/S material (termed 0\u20133\u00a0h<jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>) caused the early (within 24\u00a0h) release of greater quantities of regulatory <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, compared with uninfected controls. Elevated levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 but not pro\u2010inflammatory <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u03b1 or <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 were most evident in participants co\u2010infected with <jats:italic>S.\u00a0mansoni<\/jats:italic> and <jats:italic>S.\u00a0haematobium<\/jats:italic> and were accompanied by a higher 0\u20133\u00a0h <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>\u2010specific <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010: <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u03b1 ratio. We also report that glycosylated components within 0\u20133\u00a0h <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content> appear to be important factors in the stimulation of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u03b1 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 production by whole\u2010blood cells.<\/jats:p>","DOI":"10.1111\/pim.12028","type":"journal-article","created":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T07:54:03Z","timestamp":1360655643000},"page":"147-156","source":"Crossref","is-referenced-by-count":26,"title":["Schistosome infection is associated with enhanced whole\u2010blood <scp>IL<\/scp>\u201010 secretion in response to cercarial excretory\/secretory products"],"prefix":"10.1111","volume":"35","author":[{"given":"J. D.","family":"Turner","sequence":"first","affiliation":[{"name":"Department of Biology Centre for Immunology and Infection University of York York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Meurs","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Dool","sequence":"additional","affiliation":[{"name":"Department of Biology Centre for Immunology and Infection University of York York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. D.","family":"Bourke","sequence":"additional","affiliation":[{"name":"Department of Biology Centre for Immunology and Infection University of York York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mbow","sequence":"additional","affiliation":[{"name":"Immunology Unit of the Laboratory of Bacteriology and Virology of Aristide Le Dantec University Hospital Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. N.","family":"Di\u00e8ye","sequence":"additional","affiliation":[{"name":"Immunology Unit of the Laboratory of Bacteriology and Virology of Aristide Le Dantec University Hospital Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Mboup","sequence":"additional","affiliation":[{"name":"Immunology Unit of the Laboratory of Bacteriology and Virology of Aristide Le Dantec University Hospital Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Polman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. P.","family":"Mountford","sequence":"additional","affiliation":[{"name":"Department of Biology Centre for Immunology and Infection University of York York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70521-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro801"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69440-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000528"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2005.00789.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M500313-MCP200"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700004-MCP200"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh319"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2011.08.005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001323"},{"key":"e_1_2_6_12_1","first-page":"1440","article-title":"Immune responses during human schistosomiasis mansoni. V. Suppression of schistosome antigen\u2010specific lymphocyte blastogenesis by adherent\/phagocytic cells","volume":"122","author":"Todd CW","year":"1979","journal-title":"J Immunol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1986.35.793"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4706"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.4269\/ajtmh.1983.32.326","article-title":"Immune responses during human Schistosomiasis mansoni. VIII. Differential in vitro cellular responsiveness to adult worm and schistosomular tegumental preparations","volume":"32","author":"Gazzinelli G","year":"1983","journal-title":"The Am Journal Trop Med Hyg"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis524"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024393"},{"key":"e_1_2_6_18_1","unstructured":"WHO.Preventive chemotherapy in human helminthiasis \u2013 coordinated use of anthelminthic drugs in control interventions).2006."},{"key":"e_1_2_6_19_1","first-page":"173","article-title":"Outbreak of intestinal schistosomiasis in the Senegal River Basin","volume":"70","author":"Talla I","year":"1990","journal-title":"Ann Soc Belg Med Trop"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(92)90562-Q"},{"issue":"90","key":"e_1_2_6_21_1","first-page":"340","article-title":"The epidemiology of human schistosomiasis in the Senegal river basin","volume":"1996","author":"Picquet M","year":"1995","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(94)90400-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2012.02.002"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001829"},{"key":"e_1_2_6_25_1","first-page":"397","article-title":"A simple device for quantitative stool thick\u2010smear technique in Schistosomiasis mansoni","volume":"14","author":"Katz N","year":"1972","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.395-402.2005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.398-407.2004"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2004.03.003"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/323802"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5769(99)00015-X"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2003.11.009"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-7-139"},{"issue":"3","key":"e_1_2_6_33_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1242\/jcs.98.3.265","article-title":"Eosinophilia, activated eosinophils and human schistosomiasis","volume":"98","author":"Thorne KJ","year":"1991","journal-title":"J Cell Sci"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.24.021605.090720"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0108058"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2005.00781.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182004006390"},{"issue":"1753","key":"e_1_2_6_38_1","first-page":"S1751","article-title":"Schistosome\u2010derived omega\u20101 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor","volume":"209","author":"Everts B","year":"2012","journal-title":"J Exp Med"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12028","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:14:28Z","timestamp":1698700468000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":37,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/pim.12028"],"URL":"https:\/\/doi.org\/10.1111\/pim.12028","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}