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With multiple <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell epitopes, the abundant larval transcript\u20102 (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>\u20102) of the filarial worm, <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>rugia malayi<\/jats:italic>, has been shown to be a promising immunoprophylactic target. To enhance its efficacy, it was lipid modified using our recently developed protein engineering tool, which then offered 30% more immunoprotection (49 vs. 79%) in <jats:italic>Mastomys coucha<\/jats:italic> model. Sustained high levels of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 (about 100 times) and high antibody titres (10\u2010fold) elicited by lipid\u2010modified <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>\u20102, as compared to the native form, indicated the maintenance of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h1\/<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2 balance that is impaired in filariasis. Thus, this study provides the basis for developing efficacious vaccines for filariasis and other parasitic diseases by exploiting bacterial lipid modification.<\/jats:p>","DOI":"10.1111\/pim.12034","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T06:32:13Z","timestamp":1363588333000},"page":"201-213","source":"Crossref","is-referenced-by-count":7,"title":["Bacterial lipid modification enhances immunoprophylaxis of filarial abundant larval transcript\u20102 protein in <i><scp>M<\/scp>astomys<\/i> model"],"prefix":"10.1111","volume":"35","author":[{"given":"S.","family":"Sharmila","sequence":"first","affiliation":[{"name":"Centre for Biotechnology Anna University Chennai Tamilnadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Christiana","sequence":"additional","affiliation":[{"name":"Centre for Biotechnology Anna University Chennai Tamilnadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kiran","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Mahatma Gandhi Institute of Medical Sciences Sevagram Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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