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The human IL<\/jats:styled-content>\u201033 response to helminth antigen was analysed in Malians infected with S<\/jats:styled-content>chistosoma haematobium<\/jats:italic> by disrupting parasite integrity via chemotherapy. Plasma IL<\/jats:styled-content>\u201033 was measured pretreatment, and 24\u00a0h and 9\u00a0weeks post\u2010treatment. At 24\u00a0h post\u2010treatment, IL<\/jats:styled-content>\u201033 levels were low. Nine week post\u2010treatment IL<\/jats:styled-content>\u201033 levels were elevated and were associated with an increase in intracellular IL<\/jats:styled-content>\u201013 in eosinophils. Up\u2010regulation of intracellular IL<\/jats:styled-content>\u201013 in eosinophils was also associated with eosinophil expression of ST<\/jats:styled-content>2L, the IL<\/jats:styled-content>\u201033 receptor. IL<\/jats:styled-content>\u201033 may play an important downstream role in the human response to schistosome adult worm antigen exposure.<\/jats:p>","DOI":"10.1111\/pim.12035","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T07:05:49Z","timestamp":1364022349000},"page":"224-228","source":"Crossref","is-referenced-by-count":18,"title":["A late IL<\/scp>\u201033 response after exposure to S<\/scp>chistosoma haematobium<\/i> antigen is associated with an up\u2010regulation of IL<\/scp>\u201013 in human eosinophils"],"prefix":"10.1111","volume":"35","author":[{"given":"S.","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Pathology University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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