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In visceral leishmaniasis (<jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content>), as opposed to cutaneous leishmaniasis (<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>), parasites that infect host cells at the sand fly bite site have the striking ability to disseminate to visceral organs where they proliferate and persist for long periods of time. Imaging the dynamics of the host\u2013<jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eishmania<\/jats:italic> interaction in <jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content> provides a powerful approach to understanding the mechanisms underlying host cell invasion, <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eishmania<\/jats:italic> dissemination and persistence within visceral organs and, to dissecting the immune responses to infection. Therefore, by allowing the visualization of the critical steps involved in the pathogenesis of <jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content>, state\u2010of\u2010the\u2010art microscopy technologies have the great potential to aid in the identification of better intervention strategies for this devastating disease. In this review, we emphasize the current knowledge and the potential significance of imaging technologies in understanding the infection process of visceralizing <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eishmania<\/jats:italic> species. Then, we discuss how application of innovative microscopy technologies to the study of <jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content> will provide rich opportunities for investigating host\u2013parasite interactions at a previously unexplored level and elucidating visceral disease\u2010promoting mechanisms.<\/jats:p>","DOI":"10.1111\/pim.12044","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T11:28:33Z","timestamp":1371468513000},"page":"256-266","source":"Crossref","is-referenced-by-count":13,"title":["Imaging host\u2013<i><scp>L<\/scp>eishmani<\/i>a interactions: significance in visceral leishmaniasis"],"prefix":"10.1111","volume":"35","author":[{"given":"C.\u2010L.","family":"Forestier","sequence":"first","affiliation":[{"name":"INSERM U1095 URMITE\u2010UMR CNRS 7278 University of Aix\u2010Marseille Marseille 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