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It soon became a popular laboratory model providing a tractable experimental system that is easy to maintain in the laboratory and far more cost\u2010effective than other laboratory nematode\u2013rodent model systems. Immunity to this parasite is complex, dependent on antibodies, but confounded by the parasite's potent immunosuppressive secretions that facilitate chronic survival in murine hosts. In this review, we remind readers of the state of knowledge in the 1970s, when the first volume of <jats:italic>Parasite Immunology<\/jats:italic> was published, focusing on the role of antibodies in protective immunity. We show how our understanding of the host\u2013parasite relationship then developed over the following 35\u00a0years to date, we propose testable hypotheses for future researchers to tackle, and we speculate on how the new technologies will be applied to enable an increasingly refined understanding of the role of antibodies in host\u2010protective immunity, and its evasion, to be achieved in the longer term.<\/jats:p>","DOI":"10.1111\/pim.12057","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T10:59:27Z","timestamp":1375095567000},"page":"115-124","source":"Crossref","is-referenced-by-count":19,"title":["Understanding the role of antibodies in murine infections with <i>Heligmosomoides<\/i> (<i>polygyrus<\/i>) <i>bakeri<\/i>: 35\u00a0years ago, now and 35\u00a0years ahead"],"prefix":"10.1111","volume":"36","author":[{"given":"N. 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