{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:28:54Z","timestamp":1791404934341,"version":"4.3.3"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T00:00:00Z","timestamp":1389225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Eosinophil migration as key feature of helminth infection is increased during infection with filarial nematodes. In a mouse model of filariasis, we investigated the role of the eosinophil\u2010attracting chemokine <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>otaxin\u20101 on disease outcome. <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c and <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>otaxin\u20101<jats:sup>\u2212\/\u2212<\/jats:sup> mice were infected with the rodent filaria <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>itomosoides sigmodontis,<\/jats:italic> and parasitic parameters, cellular migration to the site of infection, and cellular responsiveness were investigated. We found increased parasite survival but unaffected eosinophil migration to the site of infection in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>otaxin\u20101<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Expression of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>80 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>86 was reduced on eosinophils from <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>otaxin\u20101<jats:sup>\u2212\/\u2212<\/jats:sup> mice after <jats:italic>in vitro <\/jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2 stimulation and exposure to filarial antigen, respectively, suggesting a potential reduced activation state of eosinophils in Eotaxin\u20101 deficient mice. We further demonstrated that macrophages from <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>otaxin\u20101<jats:sup>\u2212\/\u2212<\/jats:sup> mice produce decreased amounts of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 <jats:italic>in vitro<\/jats:italic>, a cytokine found to be associated with parasite containment, suggesting possible mechanisms by which <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>otaxin\u20101 regulates activation of inflammatory cells and thus parasite survival.<\/jats:p>","DOI":"10.1111\/pim.12079","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:26:21Z","timestamp":1381541181000},"page":"60-77","source":"Crossref","is-referenced-by-count":21,"title":["Eotaxin\u20101 is involved in parasite clearance during chronic filarial infection"],"prefix":"10.1111","volume":"36","author":[{"given":"K.","family":"Gentil","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology University Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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