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Research conducted in mouse models of schistosomiasis has provided great insights and understanding of how host protective immunity is orchestrated and key cellular populations involved in this process. Earlier studies using cytokine\u2010deficient mice demonstrated the importance of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 in mediating host survival during acute schistosomiasis. Subsequent studies employing transgenic mice carrying cell\u2010specific deletion of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u03b1 generated using the <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>re<\/jats:italic>\/<jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ox<\/jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content> recombination system have been instrumental in providing more in\u2010depth understanding of the mechanisms conferring host resistance to <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>chistosoma mansoni<\/jats:italic> infection. In this review, we will summarize the contributions of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104\/<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013\u2010responsive cellular populations in host resistance during acute schistosomiasis and their role in limiting tissue pathology.<\/jats:p>","DOI":"10.1111\/pim.12080","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T15:59:44Z","timestamp":1381852784000},"page":"421-427","source":"Crossref","is-referenced-by-count":15,"title":["Role of <scp>IL<\/scp>\u20104<scp>R<\/scp>\u03b1 during acute schistosomiasis in mice"],"prefix":"10.1111","volume":"36","author":[{"given":"H.","family":"Ndlovu","sequence":"first","affiliation":[{"name":"Division of Immunology International Center for Genetic Engineering and Biotechnology (ICGEB) Cape Town Component and Institute of Infectious Diseases and Molecular Medicine (IIDMM) University of Cape Town Cape Town 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