{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:13:42Z","timestamp":1696227222553},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T00:00:00Z","timestamp":1394150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Cutaneous leishmaniasis, caused by the parasite <jats:italic>Leishmania major<\/jats:italic>, results in lesions at the site of infection, which are self\u2010healing in resistant hosts. However, in the absence of the chemokine receptor <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>7, mice are unable to heal the lesion and develop chronic disease. These B6.<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>7<jats:sup>\u2212\/\u2212<\/jats:sup> mice display an increased number of Th2 cells and immunosuppressive cytokine levels, as well as more regulatory T cells. As <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>7 is expressed on activated dendritic cells (<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s), and these cells require <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>7 to migrate to the draining lymph node, we expected decreased migration of <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s into the lymph node in the absence of <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>7 during cutaneous leishmaniasis. Consequently, in an attempt to initiate a self\u2010healing response, we adoptively transferred <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>7<jats:sup>+<\/jats:sup> (B6.<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s into the site of infection of B6.<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>7<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Surprisingly, instead of healing the lesion, B6.<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>7<jats:sup>\u2212\/\u2212<\/jats:sup> mice inoculated with B6.<jats:styled-content style=\"fixed-case\">WT DC<\/jats:styled-content>s developed augmented lesions and showed increased immunosuppression compared to control B6.<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>7<jats:sup>\u2212\/\u2212<\/jats:sup> mice transferred with B6.<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>7<jats:sup>\u2212\/\u2212<\/jats:sup> <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s or B6.<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> mice with B6.<jats:styled-content style=\"fixed-case\">WT DC<\/jats:styled-content>s. Finally, B6.<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> mice injected with B6.<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>7<jats:sup>\u2212\/\u2212<\/jats:sup> <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s also presented delayed healing of the lesion. These results indicate that <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>7 must be expressed on <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s, as well as peripheral cells, to allow an efficient immune response to <jats:italic>L.\u00a0major<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/pim.12097","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T08:22:45Z","timestamp":1389428565000},"page":"177-185","source":"Crossref","is-referenced-by-count":3,"title":["<scp>CCR<\/scp>7 facilitates the pro\u2010inflammatory function of dendritic cells in experimental leishmaniasis"],"prefix":"10.1111","volume":"36","author":[{"given":"J. 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