{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:07:55Z","timestamp":1761217675044},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T00:00:00Z","timestamp":1400112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Summary<\/jats:title>The B<\/jats:styled-content>acillus thuringiensis <\/jats:italic>C<\/jats:styled-content>ry1A<\/jats:styled-content>c protoxin (pC<\/jats:styled-content>ry1A<\/jats:styled-content>c) is a promising mucosal immunogen and adjuvant that induces protective immunity against N<\/jats:styled-content>aegleria fowleri<\/jats:italic> and malaria infection models. We determined whether pC<\/jats:styled-content>ry1A<\/jats:styled-content>c acted as a protective adjuvant against infection with T<\/jats:styled-content>aenia crassiceps<\/jats:italic>. BALB<\/jats:styled-content>\/C<\/jats:styled-content> mice were thrice i.p. immunized with (i) pC<\/jats:styled-content>ry1A<\/jats:styled-content>c, (ii) metacestode extract, (iii) extract + pC<\/jats:styled-content>ry1A<\/jats:styled-content>c or (iv) vehicle, challenged with metacestodes on day 26 and then sacrificed 35\u00a0days later. Cysticerci in the peritoneal cavity were counted, while the serum antibody response and cytokines were analysed after immunization and during infection. Only immunization with pC<\/jats:styled-content>ry1A<\/jats:styled-content>c plus extract conferred a significant protection (up to 47%). This group presented fluctuating antibody peaks during infection and the highest I<\/jats:styled-content>gG<\/jats:styled-content>1 and I<\/jats:styled-content>gM<\/jats:styled-content> titres. Immunization with extract alone elicited high I<\/jats:styled-content>gG<\/jats:styled-content>1 and the highest I<\/jats:styled-content>gG<\/jats:styled-content>2a responses after 25\u00a0days of infection, while nonimmunized mice presented a poor, mixed\u2010T<\/jats:styled-content>h1\/T<\/jats:styled-content>h2 response during infection. Sharp peaks of TNF<\/jats:styled-content>\u03b1 and IFN<\/jats:styled-content>\u2010\u03b3 occurred immediately after the first immunization with extract, especially in the presence of pC<\/jats:styled-content>ry1A<\/jats:styled-content>c, but not after the challenge, while in the control and pC<\/jats:styled-content>ry1A<\/jats:styled-content>c\u2010alone groups, cytokines were only detected after the challenge. The data support the protective\u2010adjuvant effect of co\u2010administration of pC<\/jats:styled-content>ry1A<\/jats:styled-content>c in cysticercosis.<\/jats:p>","DOI":"10.1111\/pim.12103","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T17:18:03Z","timestamp":1391188683000},"page":"266-270","source":"Crossref","is-referenced-by-count":11,"title":["Coadministration of protoxin C<\/scp>ry1A<\/scp>c from B<\/scp>acillus thuringiensis<\/i> with metacestode extract confers protective immunity to murine cysticercosis"],"prefix":"10.1111","volume":"36","author":[{"given":"S.","family":"Ibarra\u2010Moreno","sequence":"first","affiliation":[{"name":"Laboratorio de Inmunidad en Mucosas Unidad de Biomedicina FES\u2010Iztacala Universidad Nacional Aut\u00f3noma de M\u00e9xico Tlalnepantla Estado de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L.","family":"Garc\u00eda\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunidad en Mucosas Unidad de Biomedicina FES\u2010Iztacala Universidad Nacional Aut\u00f3noma de M\u00e9xico Tlalnepantla Estado de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Moreno\u2010Fierros","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunidad en Mucosas Unidad de Biomedicina FES\u2010Iztacala Universidad Nacional Aut\u00f3noma de M\u00e9xico Tlalnepantla Estado de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.2.101"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.81693"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.01.006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.05.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182006001132"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.8.4368-4375.2004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/198921"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.10.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00436-002-0788-z","article-title":"The initial immune response during experimental cysticercosis is of the mixed Th1\/Th2 type","volume":"89","author":"Toenjes SA","year":"2003","journal-title":"Parasitol Res"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2307\/3284533"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1128\/IAI.67.5.2522-2530.1999","article-title":"Towards a Taenia solium cysticercosis vaccine: an epitope shared by Taenia crassiceps and Taenia solium protects mice against experimental cysticercosis","volume":"67","author":"Toledo A","year":"1999","journal-title":"Infect Immun"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(03)00202-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.9.5292-5297.2004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2199"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2007.02013.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1645\/GE-2483.1"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T19:50:31Z","timestamp":1696189831000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,15]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/pim.12103"],"URL":"https:\/\/doi.org\/10.1111\/pim.12103","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,15]]}}}