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Significantly low levels of B\u20101 cells and IgM antibodies were detected against a wide variety of autoantigens in microfilariae carriers as compared to endemic controls and patients with chronic pathology. A positive correlation was found between IgM antibodies to actin and ss\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>. Absorption of plasma with soluble actin, myosin and lipopolysaccharides (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>) resulted in significant removal of antifilarial antibodies. Affinity\u2010purified anti\u2010ss\u2010DNA antibodies were found to be reactive to filarial antigens and various autoantigens. Further, a positive correlation was found between polyreactive antibodies and B\u20101 cells in filarial\u2010infected human subjects. After antifilarial treatment, levels of IgM antibodies to ss\u2010DNA, actin, LPS and filarial antigen increased significantly indicating a role of polyreactive naturally occurring antibodies in filarial infection. Our findings add to the existing evidence that the B\u2010cell defect in BALB.Xid mice account for susceptibility to murine filarial infection and indicate an important role for these antibodies in providing host protection against filarial infection.<\/jats:p>","DOI":"10.1111\/pim.12105","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T22:44:41Z","timestamp":1391553881000},"page":"207-217","source":"Crossref","is-referenced-by-count":10,"title":["Bancroftian filariasis: circulating B\u20101 cells decreased in microfilaria carriers and correlate with immunoglobulin M levels"],"prefix":"10.1111","volume":"36","author":[{"given":"R.","family":"Mishra","sequence":"first","affiliation":[{"name":"Regional Medical Research Centre (ICMR) Chandrasekharpur Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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