{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:53Z","timestamp":1787015873036,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:00:00Z","timestamp":1402963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006675","name":"CNPq, INCT-DT, CAPES, FAPEMIG","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006675","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      chistosoma mansoni\n                    <\/jats:italic>\n                    is a blood fluke parasite responsible for schistosomiasis. The best long\u2010term strategy to control schistosomiasis is through immunization combined with drug treatment. In this study, we cloned, expressed and purified Sm\n                    <jats:styled-content style=\"fixed-case\">TSP<\/jats:styled-content>\n                    \u20102 fused to the N\u2010 and C\u2010terminal halves of Sm29 and tested these chimeras as vaccine candidates using an adjuvant approved to be used in humans. The results demonstrated that vaccination with Sm\n                    <jats:styled-content style=\"fixed-case\">TSP<\/jats:styled-content>\n                    \u20102 fused to N\u2010 or C\u2010terminus of Sm29\u2010induced reduction in worm burden and liver pathology when compared to control animals. Additionally, we detected high levels of mouse\u2010specific IgG, IgG1 and IgG2a against both chimeras and significant amounts of\n                    <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\n                    \u2010\u03b3 and\n                    <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                    \u2010\u03b1 and no\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20104. Finally, studies with sera from patients resistant to infection and living in schistosomiasis endemic areas revealed high levels of specific IgG to both chimeras when compared to healthy individuals. In conclusion, Sm\n                    <jats:styled-content style=\"fixed-case\">TSP<\/jats:styled-content>\n                    \u20102\/Sm29 chimeras tested here induced partial protection against infection and might be a potential vaccine candidate.\n                  <\/jats:p>","DOI":"10.1111\/pim.12118","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T04:22:47Z","timestamp":1398140567000},"page":"303-312","source":"Crossref","is-referenced-by-count":45,"title":["A multivalent chimeric vaccine composed of\n                    <i>\n                      <scp>S<\/scp>\n                      chistosoma mansoni\n                    <\/i>\n                    Sm\n                    <scp>TSP<\/scp>\n                    \u20102 and Sm29 was able to induce protection against infection in mice"],"prefix":"10.1111","volume":"36","author":[{"given":"C. S.","family":"Pinheiro","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia do Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte Brazil"},{"name":"Departamento de Biointera\u00e7\u00e3o do Instituto de ci\u00eancias da Sa\u00fade Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P. D.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia do Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. C.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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