{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:51:26Z","timestamp":1760953886340},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T00:00:00Z","timestamp":1410912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>In utero<\/jats:italic> exposure has been considered as a risk factor for filarial infection. To evaluate the influence of maternal infection on filarial\u2010specific IgG subclass response in neonates and their correlation with plasma levels IL\u201010 and interferon\u2010\u03b3, 145 pairs of mothers and their respective cord bloods were examined. Transplacental transfer of circulating filarial antigen (<jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>) was observed in 34\u00b78% cord bloods from <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content> positive mothers. Filarial\u2010specific IgG1, IgG2 and IgG4 responses of cord bloods were found to be positively correlated with <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content> of mothers. In contrast, IgG3 responses negatively correlated with <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content> of mothers. The % of similarity of recognition pattern in the cord blood with maternal blood was high for IgG3 response than IgG4 in all three groups. An increased levels of IL\u201010 and decreased levels of interferon gamma (IFN\u2010\u03b3) were observed in cord blood of infected mothers. Interferon gamma was positively correlated with IgG3 and negatively correlated with IgG4 level. On the other hand, IL\u201010 was positively correlated with IgG4 and <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>, indicating that cytokines may play a role in modulating the immune responses in cord bloods of sensitized foetus. The findings of the study reveal that <jats:italic>in utero<\/jats:italic> tolerance or sensitization may influence the filarial\u2010specific immunity to infection in neonates.<\/jats:p>","DOI":"10.1111\/pim.12121","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T15:36:46Z","timestamp":1401982606000},"page":"485-493","source":"Crossref","is-referenced-by-count":11,"title":["<i>In utero<\/i> sensitization modulates IgG isotype, IFN\u2010\u03b3 and IL\u201010 responses of neonates in bancroftian filariasis"],"prefix":"10.1111","volume":"36","author":[{"given":"K. G.","family":"Achary","sequence":"first","affiliation":[{"name":"Division of Immunology Regional Medical Research Center (Indian Council of Medical Research) Bhubaneswar Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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