{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:49:52Z","timestamp":1791132592955,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T00:00:00Z","timestamp":1410912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001794","name":"The University of Queensland","doi-asserted-by":"crossref","award":["2010000368"],"award-info":[{"award-number":["2010000368"]}],"id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"crossref"}]},{"name":"William Peter Richards Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Blastocystis<\/jats:italic> is an intestinal protist found in many species including humans and pigs. It has a controversial pathogenesis and has been implicated as a potential cause of irritable bowel syndrome. Our previous studies identified pigs as potential animal models for blastocystosis by demonstrating that they were likely natural hosts of <jats:italic>Blastocystis<\/jats:italic> and can harbour subtypes (<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>) in common with humans. Furthermore, our finding of a lack of intestinal histopathology associated with <jats:italic>Blastocystis<\/jats:italic> infection in pigs is also a consistent finding in examined infected humans. In this study, we aimed to identify and characterize the <jats:italic>Blastocystis<\/jats:italic>\u2010specific mucosal IgA response in pigs by immunoblotting, using pig faecal antibodies and <jats:italic>Blastocystis<\/jats:italic> antigen. Faeces from 233 pigs representing three age groups (sows\/boars, growers\/weaners and piglets) and including five dexamethasone\u2010immunosuppressed research pigs were tested. The majority (81\u00b75%) of the pigs had faecal IgA reactivity against <jats:italic>Blastocystis<\/jats:italic> proteins of molecular weights of 17\u00b75\u2013120\u00a0kDa. Reactivity to a &gt;250\u00a0kDa protein was found in 18\u00b75% of pigs. Notably, immunosuppressed pigs and piglets were statistically more likely to have reactivity to this protein compared to growers\/weaners and sows\/boars, respectively. These results corroborate other findings suggesting that compromised immunity may predispose to blastocystosis and support our contention that pigs are potentially good models for pathogenesis studies.<\/jats:p>","DOI":"10.1111\/pim.12123","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T12:37:23Z","timestamp":1402490243000},"page":"503-508","source":"Crossref","is-referenced-by-count":18,"title":["Characterization of the <i>Blastocystis\u2010<\/i>specific faecal IgA immune response in pigs"],"prefix":"10.1111","volume":"36","author":[{"given":"W.","family":"Wang","sequence":"first","affiliation":[{"name":"School of Veterinary Science The University of Queensland Gatton Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cuttell","sequence":"additional","affiliation":[{"name":"School of Veterinary Science The University of Queensland Gatton Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Traub","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science The University of Melbourne Parkville Vic Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Owen","sequence":"additional","affiliation":[{"name":"School of Veterinary Science The University of Queensland Gatton Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bielefeldt\u2010Ohmann","sequence":"additional","affiliation":[{"name":"School of Veterinary Science The University of Queensland Gatton Qld Australia"},{"name":"Australian Infectious Diseases Centre The University of Queensland St. Lucia Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2012.12.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.protis.2013.05.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00022-08"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2014.04.006"},{"key":"e_1_2_6_6_1","unstructured":"WangW Bielefeldt\u2010OhmannH TraubRJ et\u00a0al.Pigs as a potential animal model for blastocystosis in humans: investigating the location and pathogenic potential ofBlastocystisin porcine intestine. 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