{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:57:38Z","timestamp":1784289458563,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T00:00:00Z","timestamp":1414627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1027434"],"award-info":[{"award-number":["1027434"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DE120101701"],"award-info":[{"award-number":["DE120101701"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Scabies is an ectoparasitic infestation by the mite <jats:italic>Sarcoptes scabiei<\/jats:italic>. Although commonly self\u2010limiting, a fraction of patients develop severely debilitating crusted scabies. The immune mechanisms underlying the development of crusted scabies are unclear, and undertaking longitudinal infection studies in humans is difficult. We utilized a porcine model to compare cellular immune responses in peripheral blood and skin of pigs with different clinical manifestations of scabies (<jats:italic>n<\/jats:italic>\u00a0=\u00a012), and in uninfected controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a06). Although clinical symptoms were not evident until at least 4\u00a0weeks post\u2010infestation, the numbers of peripheral <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u03b3\u2010secreting <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells and \u03b3\u03b4 T cells increased in infected pigs from week 1 post\u2010infestation. \u03b3\u03b4 T cells remained increased in the blood at week 15 post\u2010infestation. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cell, \u03b3\u03b4 T cell and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017<jats:sup>+<\/jats:sup> cell numbers than those with ordinary scabies. Peripheral <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 levels were not increased, suggesting that localized skin <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017\u2010secreting T cells may play a critical role in the pathogenesis of crusted scabies development. Given the potential of anti\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 immunotherapy demonstrated for other inflammatory skin diseases, this study may provide a novel therapeutic avenue for patients with recurrent crusted scabies.<\/jats:p>","DOI":"10.1111\/pim.12129","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T10:37:51Z","timestamp":1404815871000},"page":"594-604","source":"Crossref","is-referenced-by-count":40,"title":["Crusted scabies is associated with increased <scp>IL<\/scp>\u201017 secretion by skin T cells"],"prefix":"10.1111","volume":"36","author":[{"given":"X.","family":"Liu","sequence":"first","affiliation":[{"name":"Inflammation &amp; Healing Research Cluster School of Health &amp; Sport Sciences University of the Sunshine Coast Maroochydore Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. F.","family":"Walton","sequence":"additional","affiliation":[{"name":"Inflammation &amp; Healing Research Cluster School of Health &amp; Sport Sciences University of the Sunshine Coast Maroochydore Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"Murray","sequence":"additional","affiliation":[{"name":"Inflammation &amp; Healing Research Cluster School of Health &amp; Sport Sciences University of the Sunshine Coast Maroochydore Qld Australia"},{"name":"QIMR Berghofer Medical Research Institute Herston Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"King","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute Herston Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Queensland Animal Science Precinct Queensland Department of Agriculture, Forestry and Fisheries University of Queensland Gatton Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. C.","family":"Holt","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Charles Darwin University Casuarina NT Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Currie","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Charles Darwin University Casuarina NT Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute Herston Qld Australia"},{"name":"School of Medicine University of Queensland Herston Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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