{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T15:28:44Z","timestamp":1759073324805,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30901353"],"award-info":[{"award-number":["30901353"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Planning Project of Guangzhou City","award":["2011J22007"],"award-info":[{"award-number":["2011J22007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Summary<\/jats:title>Systematic evaluation of the role of \u03b3\u03b4T cells during the S<\/jats:styled-content>chistosoma japonicum<\/jats:italic> infection has not been reported, despite the fact that \u03b3\u03b4T cells contribute to many infectious diseases in innate immunity. Therefore, the aim of this study was to observe the properties of \u03b3\u03b4T cells in the liver of C57BL<\/jats:styled-content>\/6 mice infected by S<\/jats:styled-content>.\u00a0japonicum<\/jats:italic>. In this report, using immuno\u2010fluorescent histological analysis, \u03b3\u03b4T cells were found around hepatic granulomatous. Moreover, the flow cytometry results revealed that the percentage of hepatic \u03b3\u03b4T cells increased significantly after S.\u00a0japonicum<\/jats:italic> infection. More interestingly, a subset of CD<\/jats:styled-content>3\u2212<\/jats:sup>\u03b3\u03b4TCR<\/jats:styled-content>+<\/jats:sup> cells were found and markedly increased after infection. Furthermore, expression of activation markers (CD<\/jats:styled-content>25 and CD<\/jats:styled-content>69) and cytokine profiles were detected in these hepatic CD<\/jats:styled-content>3+<\/jats:sup>\u03b3\u03b4TCR<\/jats:styled-content>+<\/jats:sup>and CD<\/jats:styled-content>3\u2212<\/jats:sup>\u03b3\u03b4TCR<\/jats:styled-content>+<\/jats:sup> cells. The significantly higher level of CD<\/jats:styled-content>69, IL<\/jats:styled-content>\u20104 and IL<\/jats:styled-content>\u201017 were observed in CD<\/jats:styled-content>3+<\/jats:sup>\u03b3\u03b4TCR<\/jats:styled-content>+<\/jats:sup> cells after infection, suggesting that CD<\/jats:styled-content>3+<\/jats:sup>\u03b3\u03b4TCR<\/jats:styled-content>+<\/jats:sup> cells instead of CD<\/jats:styled-content>3\u2212<\/jats:sup>\u03b3\u03b4TCR<\/jats:styled-content>+<\/jats:sup> cells might play a predominant role during the infection. Finally, our results indicated that the expression of NKG<\/jats:styled-content>2D on CD<\/jats:styled-content>3+<\/jats:sup>\u03b3\u03b4TCR<\/jats:styled-content>+<\/jats:sup> cells was higher than that on CD<\/jats:styled-content>3\u2212<\/jats:sup>\u03b3\u03b4TCR<\/jats:styled-content>+<\/jats:sup> cells. Collectively, \u03b3\u03b4T cells could play an important role in the liver of C57BL<\/jats:styled-content>\/6 mouse during japonicum<\/jats:italic> infection.<\/jats:p>","DOI":"10.1111\/pim.12135","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T05:05:26Z","timestamp":1407474326000},"page":"658-667","source":"Crossref","is-referenced-by-count":5,"title":["Immune response of \u03b3\u03b4T cells in S<\/scp>chistosome japonicum<\/i>\u2013infected C57BL<\/scp>\/6 mouse liver"],"prefix":"10.1111","volume":"36","author":[{"given":"H.","family":"Xie","sequence":"first","affiliation":[{"name":"Functional Experiment Centre Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Third Affiliated Hospital Guangzhou Medical University Guangzhou 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