{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:12:06Z","timestamp":1771629126814,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["IRTG 1673"],"award-info":[{"award-number":["IRTG 1673"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Helminths induce strong regulatory and T helper 2\u2010type responses, whereby antibody\u2010derived host protection and regulation are essential components. Lymphatic filariasis is an immune\u2010mediated spectral disease that manifests as two main clinical outcomes: chronic pathology or asymptomatic infection. These outcomes depend on a multitude of factors, including parasite\u2010induced immunoregulation and host genetic background; antibody responses contribute to this outcome. <jats:italic>N\u2010g<\/jats:italic>lycosylation of the Fc region of antibodies is a post\u2010translational modification required for the structure and molecular function, influencing host inflammatory and regulatory responses. Altered IgG glycosylation correlates with disease, whereby decreased galactosylation is associated with inflammation while increased sialylation is associated with anti\u2010inflammatory responses. We purified <jats:italic>N\u2010<\/jats:italic>linked glycans from the Fc region of total IgG from <jats:italic>Wuchereria bancrofti<\/jats:italic>\u2010infected patients characterizing the two clinical manifestations (chronic pathology and asymptomatic infection) and compared them to infection\u2010free endemic normals. Using capillary electrophoresis, we found that there was no difference in galactosylation of total IgG between the three groups; however, asymptomatically infected patients had significantly lower levels of disialylated IgG compared to endemic normals and patients with pathology. These data suggest that while galactosylation does not contribute to disease outcome, sialylation may be involved in asymptomatic infection.<\/jats:p>","DOI":"10.1111\/pim.12137","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T21:24:40Z","timestamp":1407965080000},"page":"713-720","source":"Crossref","is-referenced-by-count":16,"title":["Filariasis asymptomatically infected donors have lower levels of disialylated IgG compared to endemic normals"],"prefix":"10.1111","volume":"36","author":[{"given":"N. 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