{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:57:42Z","timestamp":1788519462255,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T00:00:00Z","timestamp":1414627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Resistance to <jats:italic><jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>hipicephalus microplus<\/jats:italic> infestation in cattle has many effector mechanisms, each of which is likely to be modulated by complex, interacting factors. Some of the mechanisms of host resistance and their modulating factors have been identified and quantified, although much remains to be explained. The variation in resistance to tick infestation is most marked between <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>os taurus<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>os indicus<\/jats:italic> cattle, taurine cattle given the same exposure carrying between five and 10 times as many ticks as indicine cattle. Tick resistance is mostly manifest against attaching larvae, which attempt to feed often and without success, death occurring mostly within 24\u00a0h of finding a host. There is evidence of innate and adaptive immune response to tick infestation, and it appears that the relative importance of each differs between indicine and taurine cattle. There is conflicting information regarding the role of humoral immunity in tick resistance, and recent studies indicate that strong <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> responses to tick antigens are not protective. A strong <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell\u2010mediated response directed against larval stages, as mounted by indicine cattle, seems to be protective. Variation in the extracellular matrix of skin (epidermal growth factors, collagens and other matrix components such as lumican) also contributes to variation in host resistance.<\/jats:p>","DOI":"10.1111\/pim.12140","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T14:33:13Z","timestamp":1413297193000},"page":"553-559","source":"Crossref","is-referenced-by-count":74,"title":["Host resistance in cattle to infestation with the cattle tick <i><scp>R<\/scp>hipicephalus microplus<\/i>"],"prefix":"10.1111","volume":"36","author":[{"given":"N. N.","family":"Jonsson","sequence":"first","affiliation":[{"name":"College of Medical Veterinary and Life Sciences University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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C.","family":"Constantinoiu","sequence":"additional","affiliation":[{"name":"James Cook University School of Veterinary and Biomedical Sciences Townsville Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1071\/AR9710159"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000118756"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6505(1998)6:3<79::AID-EVAN2>3.0.CO;2-R"},{"key":"e_1_2_6_5_1","first-page":"181","article-title":"Relative resistance of six cattle breeds to the tick Boophilus decoloratus in South Africa","volume":"58","author":"Rechav Y","year":"1991","journal-title":"Onderstepoort J Vet Res"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00052810"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.en.41.010196.000245"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1071\/AR9780885"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1071\/AR9700163"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1071\/EA08247"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.05.048"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-012-0601-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2307\/3277017"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000051386"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1071\/AR9710331"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1071\/AR9780395"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1071\/AR9780395"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(90)90077-O"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1984.4"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(89)90080-0"},{"key":"e_1_2_6_21_1","unstructured":"AcostaRR(ed).BoLA class II microsatellites associated to resistance of the cattle tick Boophilus microplus infestation. 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