{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:11:47Z","timestamp":1782321107457,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Human toxocariasis is a helminth zoonosis resulting from accidental infection of humans by the roundworms <jats:italic>Toxocara canis<\/jats:italic> (<jats:italic>T.\u00a0canis<\/jats:italic>) and <jats:italic>cati (T.\u00a0cati)<\/jats:italic>. The infection occurs in five forms: systemic (<jats:styled-content style=\"fixed-case\">VLM<\/jats:styled-content>), ocular, neurological, covert and asymptomatic. The aim of this study was to characterize the radiological and immunological findings in hepatic inflammation during the course of systemic infection by <jats:italic>Toxocara sp<\/jats:italic>. in children. Fifteen children, 2 to 17\u00a0years of age, with serological diagnosis of <jats:italic>T.\u00a0canis<\/jats:italic> infection underwent abdominal ultrasonography and computer tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>). Eosinophil counts, immunoglobulin E titres, interleukins <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b1, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, Il\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 and interferon gamma were measured for all patients. Abdominal ultrasound revealed multiple hypoechoic areas in the livers of all patients. On the <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> images, the hepatic lesions were seen as multiple, ill\u2010defined, oval low\u2010attenuating nodules that measured 6 to 9 millimetres in diameter. The nodules were usually best seen in the portal venous phase and were not seen on arterial\u2010phase images. Significant intergroup differences were observed in the concentrations of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b1, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010. The level of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 was not significantly elevated in patient sera relative to controls. The analysis shows that the production of anti\u2010inflammatory cytokines is insufficient for granuloma formation in children presenting liver lesions in the course of <jats:styled-content style=\"fixed-case\">VLM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pim.12143","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T07:16:06Z","timestamp":1409642166000},"page":"668-673","source":"Crossref","is-referenced-by-count":12,"title":["Visceral larva migrans syndrome: analysis of serum cytokine levels in children with hepatic lesions confirmed in radiological findings"],"prefix":"10.1111","volume":"36","author":[{"given":"K.","family":"Mazur\u2010Melewska","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology Karol Marcinkowski University of Medical Sciences in Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Jo\u0144czyk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology Karol Marcinkowski University of Medical Sciences Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Modli\u0144ska\u2010Cwali\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology Karol Marcinkowski University of Medical Sciences in Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Figlerowicz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology Karol Marcinkowski University of Medical Sciences in Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"S\u0142u\u017cewski","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology Karol Marcinkowski University of Medical Sciences in Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652008000200007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000400"},{"key":"e_1_2_6_4_1","first-page":"2658","article-title":"Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects","volume":"16","author":"Dispomier D","year":"2003","journal-title":"Clin Microbiol Rev"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.1976.14.1.51"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2001.39.1.1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1626-0002-0000006881"},{"key":"e_1_2_6_8_1","first-page":"72","article-title":"The cerebral form of toxocarosis in a seven\u2010year\u2010old patient","volume":"44","author":"Kazek B","year":"2006","journal-title":"Folia Neuropathol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.02000.x"},{"key":"e_1_2_6_10_1","first-page":"233","article-title":"The influence of age on a clinical presentation of\u00a0Toxocara\u00a0spp. infection in children","volume":"19","author":"Mazur\u2010Melewska K","year":"2012","journal-title":"Ann Agric Environ Med"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(05)80018-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.1416"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-007-9325-y"},{"key":"e_1_2_6_14_1","first-page":"187","article-title":"The first autochthonous infection with Dirofilaria repens\u00a0in a child in Poland","volume":"8","author":"Mazur\u2010Melewska K","year":"2013","journal-title":"J. Pediatr. Infect. Dis."},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1542\/peds.9.1.7","article-title":"Chronic eosinophilia due to visceral larva migrans: report of three cases","volume":"9","author":"Beaver PC","year":"1952","journal-title":"Paediatrics"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870200309"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950220312"},{"key":"e_1_2_6_18_1","volume-title":"Par\u00e2metros cl\u00ednicos laboratoriais na evolu\u00e7\u00e3o de 104 crian\u00e7as portadoras de larva migrans visceral por Toxocara canis [disserta\u00e7\u00e3o]","author":"Souza FA","year":"1992"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200110000-00014"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.161.3.8352109"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002619900541"},{"key":"e_1_2_6_22_1","first-page":"123","article-title":"Comparative analysis of the anti\u2010Toxocara IgG serological results obtained by a commercial ELISA and by a Western blot kit","volume":"31","author":"Danka J","year":"2004","journal-title":"Clin Exp Lab Med"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199809000-00019"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2005.06.022"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2004.03.005"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.683"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12143","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T23:39:19Z","timestamp":1696030759000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,27]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/pim.12143"],"URL":"https:\/\/doi.org\/10.1111\/pim.12143","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,27]]}}}