{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:08:52Z","timestamp":1761217732497,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2011\/24172-0"],"award-info":[{"award-number":["2011\/24172-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2012\/10415-0"],"award-info":[{"award-number":["2012\/10415-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Visceral leishmaniasis is an important parasitic disease that affects humans and animals. The response against the protozoan involves the interaction of both innate and adaptive branches of the immune system, and an important immune sensor is represented by the toll\u2010like receptor (<jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>) family. Here, we investigated the pattern of <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u20104 and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u20109 gene expression in different compartments (brain, choroid plexus, spleen and lymph node) of dogs naturally infected with <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eishmania infantum<\/jats:italic>. Gene expression of the <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>s varied according to the compartment evaluated. In the brain, there was only an upregulation of <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u20102, whereas in the choroid plexus, <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u20109 were both upregulated. Further, the peripheral lymphoid organs (spleen and lymph nodes) showed increased <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u20104 expression. This study provides the first insight about <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content> expression in the central nervous system of infected dogs, and gives additional evidence of the compartmentalization of the immune response during visceral leishmaniasis.<\/jats:p>","DOI":"10.1111\/pim.12148","type":"journal-article","created":{"date-parts":[[2014,10,4]],"date-time":"2014-10-04T10:56:57Z","timestamp":1412420217000},"page":"726-731","source":"Crossref","is-referenced-by-count":15,"title":["Compartmentalized gene expression of toll\u2010like receptors 2, 4 and 9 in the brain and peripheral lymphoid organs during canine visceral leishmaniasis"],"prefix":"10.1111","volume":"36","author":[{"given":"G. D.","family":"Melo","sequence":"first","affiliation":[{"name":"Laboratory of Applied Pathology (LApap) College of Veterinary Medicine UNESP \u2013 Univ Estadual Paulista Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Pathology (LApap) College of Veterinary Medicine UNESP \u2013 Univ Estadual Paulista Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. G.","family":"Grano","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Pathology (LApap) College of Veterinary Medicine UNESP \u2013 Univ Estadual Paulista Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. G.","family":"Homem","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine UNESP \u2013 Univ Estadual Paulista Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. F.","family":"Machado","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Pathology (LApap) College of Veterinary Medicine UNESP \u2013 Univ Estadual Paulista Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2008.04.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.10.010"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/672395"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2006.12.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009006155"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2011.03.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2012.11.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.11606\/issn.1678-4456.bjvras.2007.26653"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638712466728"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.244.2.200"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2008.10.307"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1130"},{"key":"e_1_2_7_14_1","first-page":"161","volume-title":"Manual de Vigil\u00e2ncia e Controle da Leishmaniose Visceral Americana do Estado de S\u00e3o Paulo","author":"S\u00e3o Paulo (Estado)","year":"2006"},{"key":"e_1_2_7_15_1","first-page":"215","article-title":"Serological diagnosis of visceral leishmaniasis by an enzyme immunoassay using protein A in naturally infected dogs","volume":"25","author":"Lima VMF","year":"2005","journal-title":"Braz J Vet Res Anim Sci"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2004.08.020"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2012.01.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027679"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-14-22"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2012.07.006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2004.12.020"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.03.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00603.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1457"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2012.01.016"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.10.008"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2014.05.015"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762011000500010"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.03.017"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2012.05.007"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2010.03.024"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737744"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12148","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T23:39:34Z","timestamp":1696030774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,27]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/pim.12148"],"URL":"https:\/\/doi.org\/10.1111\/pim.12148","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"type":"print","value":"0141-9838"},{"type":"electronic","value":"1365-3024"}],"subject":[],"published":{"date-parts":[[2014,11,27]]}}}