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To investigate the factors determining the expulsion of intestinal helminths, we have analysed <jats:italic>in vivo<\/jats:italic> expression of mucin genes at the site of infection in two host species displaying different compatibility with <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>chinostoma caproni<\/jats:italic> (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rematoda). Surprisingly, a general down\u2010regulation on mucin m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression was detected in low\u2010compatible hosts (rats) coinciding with the development of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2\/<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h17 responses and the early rejection of the worms from the intestinal lumen. This suggests the existence of a mechanism by which the parasites can modulate the mucus barrier to favour their survival. In highly compatible hosts (mice), some mucin genes were found to be up\u2010regulated throughout the infection, probably, to protect the intestinal epithelium against the infection\u2010induced inflammation developed in this host species. Moreover, infection\u2010induced changes on mucin glycans were also studied by lectin histochemistry. Similar alterations were detected in the ileum of infected mice and rats, except with <jats:styled-content style=\"fixed-case\">SNA<\/jats:styled-content> lectin, indicating that sylated mucins might play an important role in determining the evolution of the infection in each host species.<\/jats:p>","DOI":"10.1111\/pim.12159","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T10:46:34Z","timestamp":1415616394000},"page":"32-42","source":"Crossref","is-referenced-by-count":21,"title":["<i>Echinostoma caproni<\/i> (<scp>T<\/scp>rematoda): differential <i>in vivo<\/i> mucin expression and glycosylation in high\u2010 and low\u2010compatible hosts"],"prefix":"10.1111","volume":"37","author":[{"given":"A.","family":"Cort\u00e9s","sequence":"first","affiliation":[{"name":"Departamento de Parasitolog\u00eda Facultad de Farmacia Universidad de Valencia Burjassot Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mu\u00f1oz\u2010Antoli","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda Facultad de Farmacia Universidad de Valencia Burjassot Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sotillo","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda Facultad de Farmacia Universidad de Valencia Burjassot Valencia Spain"},{"name":"Centre for Biodiscovery and Molecular Development of Therapeutics James Cook University Smithfield Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Fried","sequence":"additional","affiliation":[{"name":"Department of Biology Lafayette College Easton PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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