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There, an array of regulatory and effector immune cells are elicited to combat the parasite through secretion of inflammatory mediators, normally resulting in host protection and pathogen control. Recent studies largely in mice have found that a productive immune response requires the combined recognition of parasite\u2010 and commensal\u2010derived antigens by mucosal leucocytes. However, despite the fine\u2010tuned regulatory mechanisms in place to prevent immunopathology, dysregulated responses can occur in genetically susceptible subjects, leading to lethal pro\u2010inflammatory\u2010mediated intestinal damage. 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