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However, the role that these proteins play in driving the unique features of<jats:italic>T.\u00a0gondii<\/jats:italic>compared to some of its nearest apicomplexan relatives (<jats:italic>Hammondia hammondi<\/jats:italic>and<jats:italic>Neospora caninum<\/jats:italic>) is unknown. These unique features include distinct dissemination characteristics<jats:italic>in vivo<\/jats:italic>and a vast host range. In this review we comprehensively survey what is known about disease outcome, the host response and host range for<jats:italic>T.\u00a0gondii<\/jats:italic>,<jats:italic>H.\u00a0hammondi<\/jats:italic>, and<jats:italic>N.\u00a0caninum<\/jats:italic>. We then review what is presently known about recently identified secreted virulence effectors in these three genetically related, but phenotypically distinct, species. Finally we exploit the existence of genome sequences for these three organisms and discuss what is known about the presence, and functionality, of key<jats:italic>T.\u00a0gondii<\/jats:italic>effectors in these three species.<\/jats:p>","DOI":"10.1111\/pim.12166","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T11:35:25Z","timestamp":1418124925000},"page":"127-140","source":"Crossref","is-referenced-by-count":29,"title":["Secreted effectors in<i>Toxoplasma gondii<\/i>and related species: determinants of host range and pathogenesis?"],"prefix":"10.1111","volume":"37","author":[{"given":"E. 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