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In particular, intracerebral T cells are crucial in the control of <jats:italic>T.\u00a0gondii<\/jats:italic> infection and are supported by essential functions from other leukocyte populations. Additionally, brain\u2010resident cells including astrocytes, microglia and neurons contribute to the intracerebral immune response by the production of cytokines, chemokines and expression of immunoregulatory cell surface molecules, such as major histocompatibility (<jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>) antigens. However, the <jats:italic>in vivo<\/jats:italic> behaviour of these individual cell populations, specifically their interaction during cerebral toxoplasmosis, remains to be elucidated. We discuss here what is known about the function of T cells, recruited myeloid cells and brain\u2010resident cells, with particular emphasis on the potential cross\u2010regulation of these cell populations, in governing cerebral toxoplasmosis.<\/jats:p>","DOI":"10.1111\/pim.12173","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T07:05:49Z","timestamp":1420787149000},"page":"150-158","source":"Crossref","is-referenced-by-count":98,"title":["Persistence of <i>Toxoplasma gondii<\/i> in the central nervous system: a fine\u2010tuned balance between the parasite, the brain and the immune system"],"prefix":"10.1111","volume":"37","author":[{"given":"N.","family":"Blanchard","sequence":"first","affiliation":[{"name":"Inserm U1043 Toulouse France"},{"name":"CNRS U5282 Toulouse France"},{"name":"Centre de Physiopathologie de Toulouse Purpan (CPTP) Universit\u00e9 de Toulouse UPS Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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