{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:31:52Z","timestamp":1756463512514},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T00:00:00Z","timestamp":1434499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Morbidity and mortality caused by schistosomiasis usually results from immunopathology. But the underlying mechanisms are not yet clearly understood. Th2\u2010type immune response is thought to be dominant during chronic schistosomiasis, and upregulation of arginase\u2010I is one component of this milieu. A cohort study was conducted to assess arginase activity in peripheral blood of humans with intestinal schistosomiasis in Wonji\u2010Shoa Sugar Estate, Central Ethiopia. Laboratory\u2010confirmed 30 <jats:italic>Schistosoma mansoni<\/jats:italic>\u2010infected patients and 18 apparently healthy controls were recruited. Faecal egg count was carried out by Kato\u2010Katz technique. Plasma and peripheral blood mononuclear cells (PBMCs) were isolated from whole blood. Activity of arginase in plasma and PBMC lysates was measured, and results were compared with that of controls. Twenty\u2010one of 30 patients had light infection, whereas moderate and heavy intensity infections were observed in eight and only one patient(s), respectively. A significant increase in both PBMC (patients: 59\u00b796\u00a0+\u00a082\u00b799, controls: 25\u00b744\u00a0+\u00a024\u00b76\u00a0mU\/mg protein, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001) and plasma (patients: 1\u00b761\u00a0+\u00a02\u00b719, controls: 0\u00b731\u00a0+\u00a00\u00b773\u00a0mU\/mL plasma, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001) arginase activity was observed during human <jats:italic>S.\u00a0mansoni<\/jats:italic> infection. Arginase activity increases in peripheral blood of patients with intestinal schistosomiasis.<\/jats:p>","DOI":"10.1111\/pim.12186","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T16:26:49Z","timestamp":1426696009000},"page":"380-383","source":"Crossref","is-referenced-by-count":5,"title":["Arginase activity in peripheral blood of patients with intestinal schistosomiasis, <scp>W<\/scp>onji, <scp>C<\/scp>entral <scp>E<\/scp>thiopia"],"prefix":"10.1111","volume":"37","author":[{"given":"A.","family":"Getaneh","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science Arba Minch University Arba Minch Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tamrat","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology Addis Ababa University Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Tadesse","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology Addis Ababa University Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66457-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(00)00122-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2009.01098.x"},{"key":"e_1_2_7_5_1","first-page":"1242","volume-title":"Harrison's Principles of Internal Medicine","author":"Mahmoud AAF","year":"2001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.146.4.1322"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.6.1616S"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00291.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001684"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002134"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001977"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u2010695X.2012.01012.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/653736"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1921"},{"key":"e_1_2_7_15_1","first-page":"397","article-title":"A simple device for quantitative stool thick\u2010smear technique in Schistosomiasis mansoni","volume":"14","author":"Katz N","year":"1972","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636542"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141869"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00107-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000371"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902009"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000947"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1109737"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2008.06.015"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12186","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T15:28:26Z","timestamp":1696001306000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,17]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/pim.12186"],"URL":"https:\/\/doi.org\/10.1111\/pim.12186","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,17]]}}}