{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:50Z","timestamp":1740126050761,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T00:00:00Z","timestamp":1441670400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["TM597"],"award-info":[{"award-number":["TM597"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1517313N\/KN251"],"award-info":[{"award-number":["1517313N\/KN251"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Interuniversity Attraction Pole Program PAI-IAP","award":["P7\/41"],"award-info":[{"award-number":["P7\/41"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>African trypanosomes infect humans and animals throughout the African continent. These parasites maintain chronic infections by various immune evasion strategies. While antigenic variation of their surface coat is the most studied strategy linked to evading the host humoral response, African trypanosomes also induce impaired B\u2010cell lymphopoiesis, the destruction of the splenic B\u2010cell compartment and abrogation of protective memory responses. Here we investigate the mechanism of follicular B\u2010cell destruction. We show that during infection follicular B cells undergo apoptosis, correlating to enhanced Fas death receptor surface expression. Investigation of various type 1 cytokine knockout mice indicates a crucial role of IFN\u2010\u03b3 in the early onset of FoB cell destruction. Indeed, both IFN\u2010\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup> and IFN\u2010\u03b3R<jats:sup>\u2212\/\u2212<\/jats:sup> mice are protected from trypanosomosis\u2010associated FoB cell depletion, exhibiting an inhibition of B\u2010cell apoptosis as well as a reduced activation of FoB cells during the first week post\u2010infection. The data presented herein offer new insights into B\u2010cell dysfunctioning during experimental African trypanosome infections.<\/jats:p>","DOI":"10.1111\/pim.12208","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T12:13:01Z","timestamp":1434370381000},"page":"479-484","source":"Crossref","is-referenced-by-count":18,"title":["IFN\u2010\u03b3 mediates early B\u2010cell loss in experimental African trypanosomosis"],"prefix":"10.1111","volume":"37","author":[{"given":"J.","family":"Cnops","sequence":"first","affiliation":[{"name":"Laboratory for Cellular and Molecular Immunology Vrije Universiteit Brussel Brussels Belgium"},{"name":"Department of Structural Biology SBRC VIB Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"De Trez","sequence":"additional","affiliation":[{"name":"Laboratory for Cellular and Molecular Immunology Vrije Universiteit Brussel Brussels Belgium"},{"name":"Department of Structural Biology SBRC VIB Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bulte","sequence":"additional","affiliation":[{"name":"Laboratory for Cellular and Molecular Immunology Vrije Universiteit Brussel Brussels Belgium"},{"name":"Department of Structural Biology SBRC VIB Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Radwanska","sequence":"additional","affiliation":[{"name":"Ghent University Global Campus Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Ryffel","sequence":"additional","affiliation":[{"name":"Experimental and Molecular Immunology and Neurogenetics UMR 7355 CNRS\u2010University of Orleans and IDM University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Magez","sequence":"additional","affiliation":[{"name":"Laboratory for Cellular and Molecular Immunology Vrije Universiteit Brussel Brussels Belgium"},{"name":"Department of Structural Biology SBRC VIB Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,8]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.2307\/3281038"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4049\/jimmunol.140.1.283","article-title":"Genetics of resistance to the African trypanosomes VI. 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