{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:49Z","timestamp":1740126049728,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T00:00:00Z","timestamp":1441670400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["TM597"],"award-info":[{"award-number":["TM597"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>African trypanosomosis is a parasitic disease affecting both humans (<jats:italic>sleeping sickness<\/jats:italic>) and animals (<jats:italic>nagana<\/jats:italic>). In murine trypanosomosis, the B\u2010cell compartment is rapidly destroyed after infection. In addition, B\u2010cell lymphopoiesis in the bone marrow is abrogated, B\u2010cell subsets in the spleen are irreversibly depleted, and B\u2010cell memory is destroyed. Here, we investigated the effect of cure of infection on the B\u2010cell compartment. Suramin and diminazene aceturate were used in this study as these drugs exhibit different modes of uptake and different mechanisms of trypanocidal action. Curative drug treatment of trypanosomosis infection led to the re\u2010initiation of B\u2010cell lymphopoiesis in the bone marrow, and to the repopulation of splenic B\u2010cell subsets, independent of the drug used. Neither of these drugs by itself induced measurable effects on B\u2010cell lymphopoiesis in the bone marrow or B\u2010cell homoeostasis in the spleen in healthy, na\u00efve animals.<\/jats:p>","DOI":"10.1111\/pim.12209","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T07:03:21Z","timestamp":1434179001000},"page":"485-491","source":"Crossref","is-referenced-by-count":6,"title":["Curative drug treatment of trypanosomosis leads to the restoration of B\u2010cell lymphopoiesis and splenic B\u2010cell compartments"],"prefix":"10.1111","volume":"37","author":[{"given":"J.","family":"Cnops","sequence":"first","affiliation":[{"name":"Laboratory for Cellular and Molecular Immunology Vrije Universiteit Brussel Brussels Belgium"},{"name":"Department of Structural Biology VIB Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Bockstal","sequence":"additional","affiliation":[{"name":"Laboratory for Cellular and Molecular Immunology Vrije Universiteit Brussel Brussels Belgium"},{"name":"Department of Structural Biology VIB Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"De Trez","sequence":"additional","affiliation":[{"name":"Laboratory for Cellular and Molecular Immunology Vrije Universiteit Brussel Brussels Belgium"},{"name":"Department of Structural Biology VIB Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Miquel","sequence":"additional","affiliation":[{"name":"University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Radwanska","sequence":"additional","affiliation":[{"name":"Songdo Global University Foundation Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Magez","sequence":"additional","affiliation":[{"name":"Laboratory for Cellular and Molecular Immunology Vrije Universiteit Brussel Brussels Belgium"},{"name":"Department of Structural Biology VIB Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,8]]},"reference":[{"unstructured":"WHO.Report of a WHO meeting on elimination of African trypanosomiasis (Trypanosoma brucei gambiense).2012;(December).","key":"e_1_2_5_2_1"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.1371\/journal.ppat.1000122"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1128\/iai.32.3.979-984.1981","article-title":"Immune depression and macroglobulinemia in experimental subchronic Trypanosomiasis","volume":"32","author":"Baltz T","year":"1981","journal-title":"Infect 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