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It has been demonstrated that nitric oxide,\n                    <jats:italic>mast cells<\/jats:italic>\n                    and dendritic cells are the first line of defence against\n                    <jats:italic>Giardia<\/jats:italic>\n                    .\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20106 and\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017 play an important role during infection. Several cytokines possess overlapping functions in regulating innate and adaptive immune responses. IgA and\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4\n                    <jats:sup>+<\/jats:sup>\n                    T cells are fundamental to the process of\n                    <jats:italic>Giardia<\/jats:italic>\n                    clearance. It has been suggested that\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4\n                    <jats:sup>+<\/jats:sup>\n                    T cells play a double role during the anti\u2010\n                    <jats:italic>Giardia<\/jats:italic>\n                    immune response. First, they activate and stimulate the differentiation of B cells to generate\n                    <jats:italic>Giardia<\/jats:italic>\n                    \u2010specific antibodies. Second, they act through a B\u2010cell\u2010independent mechanism that is probably mediated by Th17 cells. Several\n                    <jats:italic>Giardia<\/jats:italic>\n                    proteins that stimulate humoral and cellular immune responses have been described. Variant surface proteins, \u03b1\u20101 giardin, and cyst wall protein 2 can induce host protective responses to future\n                    <jats:italic>Giardia<\/jats:italic>\n                    challenges. The characterization and evaluation of the protective potential of the immunogenic proteins that are associated with\n                    <jats:italic>Giardia<\/jats:italic>\n                    will offer new insights into host\u2013parasite interactions and may aid in the development of an effective vaccine against the parasite.\n                  <\/jats:p>","DOI":"10.1111\/pim.12210","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T08:19:31Z","timestamp":1434183571000},"page":"394-406","source":"Crossref","is-referenced-by-count":60,"title":["Host defences against\n                    <i>Giardia lamblia<\/i>"],"prefix":"10.1111","volume":"37","author":[{"given":"G.","family":"Lopez\u2010Romero","sequence":"first","affiliation":[{"name":"Coordinaci\u00f3n de Nutrici\u00f3n Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo A.C. Hermosillo Sonora M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Quintero","sequence":"additional","affiliation":[{"name":"Department of Chemistry\u2013Biology University of Sonora Hermosillo Sonora M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Astiazar\u00e1n\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n de Nutrici\u00f3n Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo A.C. 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