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It was recently shown that the <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\u20101 family transcription factor <jats:styled-content style=\"fixed-case\">JUNB<\/jats:styled-content> positively regulates macrophage activation in response to Toll\u2010like receptor agonists that promote classical or M1 polarization, as well as to the cytokine interleukin\u20104 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104), which elicits an alternatively activated or M2 phenotype. However, a role for <jats:styled-content style=\"fixed-case\">JUNB<\/jats:styled-content> in macrophage activation has never been demonstrated <jats:italic>in\u00a0vivo<\/jats:italic>. Here, to dissect the role of <jats:styled-content style=\"fixed-case\">JUNB<\/jats:styled-content> in macrophage activation in a physiological setting, mice lacking <jats:styled-content style=\"fixed-case\">JUNB<\/jats:styled-content> specifically in myeloid cells were tested in two infection models: experimental cerebral malaria, which elicits a pathological type 1 immune response, and helminth infection, in which type 2 responses are protective. Myeloid\u2010restricted deletion of <jats:italic>Junb<\/jats:italic> reduced type 1 immune activation, which was associated with reduced cerebral pathology and improved survival during infection with <jats:italic>Plasmodium berghei<\/jats:italic>. Myeloid <jats:styled-content style=\"fixed-case\">JUNB<\/jats:styled-content> deficiency also compromised type 2 activation during infection with the hookworm <jats:italic>Nippostrongylus brasiliensis<\/jats:italic>, leading to diminished cytokine production and eosinophil recruitment and increased parasite burden. These results demonstrate that <jats:styled-content style=\"fixed-case\">JUNB<\/jats:styled-content> in myeloid cells shapes host responses and outcomes during type 1 and type 2 infections.<\/jats:p>","DOI":"10.1111\/pim.12215","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T18:25:05Z","timestamp":1436898305000},"page":"470-478","source":"Crossref","is-referenced-by-count":13,"title":["Myeloid expression of the <scp>AP<\/scp>\u20101 transcription factor <scp>JUNB<\/scp> modulates outcomes of type 1 and type 2 parasitic infections"],"prefix":"10.1111","volume":"37","author":[{"given":"M. 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