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Their survival is typically associated with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2\u2010biased immune responses and immunosuppressive effects and depends on the parasite's ability to excrete\/secrete antigens with immunoregulatory properties. Here, <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>esocestoides vogae,<\/jats:italic> a natural parasite of mice, is proposed as a new model species for the identification and characterization of cestode\u2010derived immunomodulatory factors. We followed the kinetics of immune parameters after infection with <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>.\u00a0vogae<\/jats:italic> or exposure to their excretory\/secretory (<jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>) products in a permissive strain of mice. Besides, a dominant <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 production and accumulation of macrophages and eosinophils expressing <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> for Fizz\u20101, YM1 and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rg\u20101, mice showed minimal <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 and transient <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 production at early time points with a complete loss at later stages of infection. We found that serum\u2010free <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content> products without host contamination directly induced <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>2 macrophages and suppressed <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 production <jats:italic>in\u00a0vivo<\/jats:italic> and <jats:italic>in\u00a0vitro<\/jats:italic>. This study highlights the use of the <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>.\u00a0vogae<\/jats:italic> as a cestode infection model and its <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content> products as a valuable tool for the identification of new therapeutic targets for the control of larval cestodiasis.<\/jats:p>","DOI":"10.1111\/pim.12216","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T11:23:17Z","timestamp":1437996197000},"page":"493-504","source":"Crossref","is-referenced-by-count":14,"title":["Immunity and immune modulation elicited by the larval cestode <i><scp>M<\/scp>esocestoides vogae<\/i> and its products"],"prefix":"10.1111","volume":"37","author":[{"given":"E.","family":"Vendelova","sequence":"first","affiliation":[{"name":"Institute of Parasitology of the Slovak Academy of Sciences Ko\u0161ice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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