{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:52:09Z","timestamp":1781279529175,"version":"3.54.1"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T00:00:00Z","timestamp":1445817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IN217913"],"award-info":[{"award-number":["IN217913"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Leishmania mexicana<\/jats:italic> is the causal agent of cutaneous leishmaniasis in Mexico. Dendritic cells (DC) are one of the host cells of <jats:italic>Leishmania<\/jats:italic> parasites. Intracellular microorganisms inhibit host cell apoptosis as a strategy to ensure their survival in infected cells. We have previously shown that <jats:italic>Leishmania mexicana<\/jats:italic> promastigotes and amastigotes inhibit camptothecin\u2010induced apoptosis of monocyte\u2010derived dendritic cells (moDC), but the mechanisms underlying the inhibition of apoptosis of DC by <jats:italic>Leishmania<\/jats:italic> have not been established. MAP kinases and PI3K participate in the process of apoptosis and are modulated by different species of <jats:italic>Leishmania<\/jats:italic>. As shown in this study, the infection of moDC with <jats:italic>L.\u00a0mexicana<\/jats:italic> amastigotes diminished significantly the phosphorylation of the MAP kinases p38 and JNK. The inhibition of both kinases diminished significantly DNA fragmentation in moDC stimulated with camptothecin. On the other hand, <jats:italic>L.\u00a0mexicana<\/jats:italic> amastigotes were able to activate the anti\u2010apoptotic pathways PI3K and AKT. Our results indicate that <jats:italic>L.\u00a0mexicana<\/jats:italic> amastigotes have the capacity to diminish MAP kinases activation and activate PI3K and AKT, which is probably one of the strategies employed by <jats:italic>L.\u00a0mexicana<\/jats:italic> amastigotes to inhibit apoptosis in the infected moDC.<\/jats:p>","DOI":"10.1111\/pim.12275","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T19:18:01Z","timestamp":1441826281000},"page":"579-589","source":"Crossref","is-referenced-by-count":26,"title":["<i>Leishmania mexicana<\/i> amastigotes inhibit p38 and JNK and activate PI3K\/AKT: role in the inhibition of apoptosis of dendritic cells"],"prefix":"10.1111","volume":"37","author":[{"given":"R.","family":"V\u00e1zquez\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda y Parasitolog\u00eda Facultad de Ciencias de la Salud Av. 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