{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:46:37Z","timestamp":1777441597519,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["INI_X_2013_1_101090"],"award-info":[{"award-number":["INI_X_2013_1_101090"]}],"id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Cystic echinococcosis is a zoonotic disease caused by the cestode parasite <jats:italic>Echinococcus granulosus<\/jats:italic>. In endemic regions, seropositive individuals to <jats:italic>E.\u00a0granulosus<\/jats:italic> usually and markedly outnumber image\u2010confirmed cases of cystic echinococcosis, suggesting that some parasite challenges derive in unsuccessful infection establishments. However, it is still unknown whether such parasite\u2010specific antibodies in healthy individuals might play a role in resistance\/susceptibility to the infection. Therefore, we have here analysed the profile of antibodies recognizing <jats:italic>E.\u00a0granulosus<\/jats:italic> antigens in seropositive but ultrasound normal individuals, as well as in surgery\u2010confirmed patients and healthy donors. Our results showed that ultrasound normal individuals exhibited low avidity IgG antibodies, as well as low levels of parasite\u2010specific IgG1 and IgG4 antibodies. In addition, they displayed significant levels of specific IgE, and thus, they revealed a uniquely high IgE:IgG4 ratio. Moreover, high levels of parasite\u2010specific IgM were detected in such individuals, which showed characteristics of natural cross\u2010reacting antibodies. Therefore, our results indicate that ultrasound normal individuals but seropositive for <jats:italic>E.\u00a0granulosus<\/jats:italic> antigens exhibit a distinctive antibody profile. In this regard, possible associations between their antiparasite antibodies and potential resistance mechanisms to cystic echinococcosis are discussed.<\/jats:p>","DOI":"10.1111\/pim.12302","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T04:58:54Z","timestamp":1451969934000},"page":"93-100","source":"Crossref","is-referenced-by-count":6,"title":["Antibody profiling in ultrasound normal individuals with positive serology for cystic echinococcosis"],"prefix":"10.1111","volume":"38","author":[{"given":"G.","family":"Mourglia\u2010Ettlin","sequence":"first","affiliation":[{"name":"Facultad de Qu\u00edmica\/Facultad de Ciencias C\u00e1tedra de Inmunolog\u00eda \u2010 DEPBIO\/IQB Universidad de la Rep\u00fablica Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Miles","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica\/Facultad de Ciencias C\u00e1tedra de Inmunolog\u00eda \u2010 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