{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T04:47:11Z","timestamp":1774846031743,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The role of tumour necrosis factor\u2010alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) is not fully understood in human leishmaniasis. We analysed the alterations in the levels of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1, soluble <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> receptor type 1 (<jats:styled-content style=\"fixed-case\">sTNFR<\/jats:styled-content> I), <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 productions in active and healed leishmaniases. Blood samples were collected from volunteers with active cutaneous leishmaniasis (<jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content>), the same subjects after lesion healing (healed <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00a0=\u00a0<jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content>), volunteers with active visceral leishmaniasis (<jats:styled-content style=\"fixed-case\">AVL<\/jats:styled-content>), healed <jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HVL<\/jats:styled-content>) and healthy controls. Levels of cytokines were titrated on <jats:italic>Leishmania<\/jats:italic> Ag\u2010stimulated <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content> culture. The mean level of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 production from stimulated cells was significantly higher in <jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content> than controls (P\u00a0&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001) and significantly reduced after treatment in <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> volunteers (P\u00a0&lt;\u00a00\u00b705). The mean level of <jats:styled-content style=\"fixed-case\">sTNFR<\/jats:styled-content> I production was significantly higher in <jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content> than controls (P\u00a0&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001) and significantly reduced after treatment in <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> volunteers (P\u00a0&lt;\u00a00\u00b705). The mean level of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 production in <jats:styled-content style=\"fixed-case\">AVL<\/jats:styled-content> was significantly higher than controls (P\u00a0&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b705) and was significantly lower in <jats:styled-content style=\"fixed-case\">HVL<\/jats:styled-content> compared with <jats:styled-content style=\"fixed-case\">AVL<\/jats:styled-content> (P\u00a0&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001) and controls (P\u00a0&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b705). The levels of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 (P\u00a0=<jats:italic>\u00a0<\/jats:italic>0\u00b70025) and <jats:styled-content style=\"fixed-case\">sTNFR<\/jats:styled-content> I (P\u00a0&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b701) productions from <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>s showed significant decreasing trend after treatment in each <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content> volunteer. Reduction in <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 is associated with clinical response to treatment and healing of <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content> lesions due to <jats:italic>L.\u00a0major<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/pim.12305","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T12:38:56Z","timestamp":1453898336000},"page":"255-260","source":"Crossref","is-referenced-by-count":15,"title":["Tumour Necrosis Factor\u2010alpha (<scp>TNF<\/scp>\u2010\u03b1) and its soluble receptor type\u00a01 (<scp>sTNFR<\/scp> I) in human active and healed leishmaniases"],"prefix":"10.1111","volume":"38","author":[{"given":"M.","family":"Nateghi Rostami","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Faculty of Medicine Qom University of Medical Sciences Qom Iran"},{"name":"Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Seyyedan Jasbi","sequence":"additional","affiliation":[{"name":"Department of Microbiology Qom Branch Islamic Azad University Qom Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Khamesipour","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.06.023"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.59"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.617-621.2005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.3.1962"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000845"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9788-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2012.02.006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-14-52"},{"key":"e_1_2_6_11_1","first-page":"2379","article-title":"IL\u201017 and IL\u201022 are associated with protection against human kala azar caused by Leishmania donovani","volume":"119","author":"Pitta MG","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2005.06.004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822002000100002"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761996000200019"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.10-0680"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(01)00194-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.07.003"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1684\/ecn.2012.0307","article-title":"Altered serum pro\u2010inflammatory cytokines in children with Down's syndrome","volume":"23","author":"Nateghi Rostami M","year":"2012","journal-title":"Eur Cytokine Netw"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2012.11.006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652009000500002"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.01.007"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.03.011"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-007-0056-z"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737662"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2012.07.001"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762012000600005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2000.00011.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"768","DOI":"10.4049\/jimmunol.153.2.768","article-title":"Role and effect of TNF\u2010alpha in experimental visceral leishmaniasis","volume":"153","author":"Tumang MC","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03761.x"},{"key":"e_1_2_6_30_1","first-page":"478","article-title":"Plasma levels of tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), TNF\u2010\u03b1 soluble receptor type 1 (sTNFR I) and IL\u201022 in human leishmaniasis","volume":"32","author":"Nateghi Rostami M","year":"2015","journal-title":"Trop Biomed"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:37:55Z","timestamp":1696167475000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,30]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/pim.12305"],"URL":"https:\/\/doi.org\/10.1111\/pim.12305","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,30]]}}}