{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T07:29:43Z","timestamp":1785914983461,"version":"3.56.0"},"reference-count":69,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004418","name":"Vrije Universiteit Brussel","doi-asserted-by":"publisher","award":["DP\/AP\/JV\/dbd\/BEURS\/451"],"award-info":[{"award-number":["DP\/AP\/JV\/dbd\/BEURS\/451"]}],"id":[{"id":"10.13039\/501100004418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Leishmania donovani<\/jats:italic> is a protozoan parasite causing the neglected tropical disease visceral leishmaniasis. One difficulty to study the immunopathology upon <jats:italic>L.\u00a0donovani<\/jats:italic> infection is the limited adaptability of the strains to experimental mammalian hosts. Our knowledge about <jats:italic>L.\u00a0donovani<\/jats:italic> infections relies on a restricted number of East African strains (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>9, 1S). Isolated from patients in the 1960s, these strains were described extensively in mice and Syrian hamsters and have consequently become \u2018reference\u2019 laboratory strains. <jats:italic>L.\u00a0donovani<\/jats:italic> strains from the Indian continent display distinct clinical features compared to East African strains. Some reports describing the <jats:italic>in\u00a0vivo<\/jats:italic> immunopathology of strains from the Indian continent exist. This study comprises a comprehensive immunopathological characterization upon infection with two additional strains, the Ethiopian <jats:italic>L.\u00a0donovani<\/jats:italic> L82 strain and the Nepalese <jats:italic>L.\u00a0donovani <\/jats:italic><jats:styled-content style=\"fixed-case\">BPK<\/jats:styled-content>282 strain in both Syrian hamsters and C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice. Parameters that include parasitaemia levels, weight loss, hepatosplenomegaly and alterations in cellular composition of the spleen and liver, showed that the L82 strain generated an overall more virulent infection compared to the <jats:styled-content style=\"fixed-case\">BPK<\/jats:styled-content>282 strain. Altogether, both <jats:italic>L.\u00a0donovani<\/jats:italic> strains are suitable and interesting for subsequent <jats:italic>in\u00a0vivo<\/jats:italic> investigation of visceral leishmaniasis in the Syrian hamster and the C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mouse model.<\/jats:p>","DOI":"10.1111\/pim.12316","type":"journal-article","created":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T09:27:48Z","timestamp":1458898068000},"page":"290-302","source":"Crossref","is-referenced-by-count":3,"title":["<i>In vivo<\/i> characterization of two additional <i>Leishmania donovani<\/i> strains using the murine and hamster model"],"prefix":"10.1111","volume":"38","author":[{"given":"F.","family":"Kauffmann","sequence":"first","affiliation":[{"name":"Laboratory of Cellular and Molecular Immunology (CMIM) Vrije Universiteit Brussel (VUB) Brussels Belgium"},{"name":"Department of Structural Biology Research Center Vlaams Instituut voor Biotechnologie 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