{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:05:54Z","timestamp":1758819954748},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T00:00:00Z","timestamp":1464566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["E013929"],"award-info":[{"award-number":["E013929"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["086852"],"award-info":[{"award-number":["086852"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008925","name":"American Asthma Foundation","doi-asserted-by":"publisher","award":["09\u20100125"],"award-info":[{"award-number":["09\u20100125"]}],"id":[{"id":"10.13039\/100008925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\u201062 is a glycoprotein secreted by the filarial nematode <jats:italic>Acanthocheilonema viteae<\/jats:italic> that protects against ovalbumin (<jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>)\u2010induced airway hyper\u2010responsiveness in mice by virtue of covalently attached anti\u2010inflammatory phosphorylcholine (<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>) residues. We have recently generated a library of small molecule analogues (<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>s) of <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\u201062 based around its active <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> moiety as a starting point in novel drug development for asthma and identified two compounds \u2013 termed 11a and 12b \u2013 that mirror <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\u201062's protective effects. In this study, we have moved away from <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>, a model allergen, to test the <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>s against two clinically relevant allergens \u2013 house dust mite (<jats:styled-content style=\"fixed-case\">HDM<\/jats:styled-content>) and cockroach allergen (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) extract. We show that both <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>s offer some protection against development of lung allergic responses to <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>, in particular reducing eosinophil infiltration, whereas only <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> 12b is effective in protecting against eosinophil\u2010dependent <jats:styled-content style=\"fixed-case\">HDM<\/jats:styled-content>\u2010induced allergy. These data therefore suggest that helminth molecule\u2010induced protection against model allergens may not necessarily translate to clinically relevant allergens. Nevertheless, in this study, we have managed to demonstrate that it is possible to produce synthetic drug\u2010like molecules based on a parasitic worm product that show therapeutic potential with respect to asthma resulting from known triggers in humans.<\/jats:p>","DOI":"10.1111\/pim.12322","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T12:37:59Z","timestamp":1460291879000},"page":"340-351","source":"Crossref","is-referenced-by-count":7,"title":["Testing small molecule analogues of the <i>Acanthocheilonema viteae<\/i> immunomodulator <scp>ES<\/scp>\u201062 against clinically relevant allergens"],"prefix":"10.1111","volume":"38","author":[{"given":"L.","family":"Janicova","sequence":"first","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Rzepecka","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. T.","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Doonan","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. S.","family":"Bell","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. E.","family":"Lumb","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Suckling","sequence":"additional","affiliation":[{"name":"Department of Pure &amp; Applied Chemistry University of Strathclyde Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Harnett","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Harnett","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/15665240113139990057"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12164"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400927"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/821578"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1654"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2012.12.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2014.05.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112691"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-7-22"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm401251p"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.10.016"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.12.010"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36130"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12208"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042572"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2012.10.014"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108189200"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2015.03.025"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315591031"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.07.004"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34581"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.04.005"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"54.55","DOI":"10.4049\/jimmunol.188.Supp.54.5","article-title":"Modulation of IL\u201017A and TL1A largely abrogates house dust mite\u2010induced lung inflammation in a murine model of allergic airway disease","volume":"188","author":"Hubeau C","year":"2012","journal-title":"J Immunol"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19224"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.4.2059"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12322","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:05:33Z","timestamp":1696190733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,30]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/pim.12322"],"URL":"https:\/\/doi.org\/10.1111\/pim.12322","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,30]]}}}