{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T06:45:12Z","timestamp":1759041912592},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["602051"],"award-info":[{"award-number":["602051"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with cystic echinococcosis (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>) can harbour cysts for years or even decades, apparently without effect of the immune system on the metacestode. Although several immune evasion mechanisms by echinococcal cysts have been described, it is unclear whether the human leucocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) system plays a role in the susceptibility or resistance to <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> in humans. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G molecules are known to exert a suppressive action on dendritic cells maturation and on natural killer (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>) cells functions, therefore hampering T\u2010cell responses and <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cytolysis. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G plays an important role in immune tolerance, is involved in foetus and in allotransplant tolerance, and may be involved in tumoral and viral immune evasion. In this study, we assessed the presence and levels of soluble <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G (<jats:styled-content style=\"fixed-case\">sHLA<\/jats:styled-content>\u2010G) in patients with <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> using a commercial <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> kit to determine whether host's <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G may have a role in the course of human <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pim.12328","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T23:41:04Z","timestamp":1461800464000},"page":"414-418","source":"Crossref","is-referenced-by-count":4,"title":["Correlation of serum <scp>sHLA<\/scp>\u2010G levels with cyst stage in patients with cystic echinococcosis: is it an immune evasion 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