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The aim of this study was to investigate allergy\u2010related immune markers in children naturally infected with <jats:italic>Cryptosporidium<\/jats:italic>. In a cross\u2010sectional study, 49 children with or without clinical diagnosis of allergies, oocysts of <jats:italic>Cryptosporidium<\/jats:italic> spp. in the faeces were screened microscopically. We microscopically screened for leucocytes, examined T and B cells for allergy\u2010related activation markers using flow cytometry and evaluated serum for total IgE using chemiluminescence. Children with allergies and <jats:italic>Cryptosporidium<\/jats:italic> in the faeces had significantly lower levels of total IgE, B cells, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>23<jats:sup>+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>124<jats:sup>+<\/jats:sup> cells as well as a greater percentage of interferon\u2010gamma (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3<jats:sup>+<\/jats:sup>) and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> cells than children with allergies without <jats:italic>Cryptosporidium<\/jats:italic>. This is the first description of the modulation of the <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> in children with allergic diseases in the setting of natural <jats:italic>Cryptosporidium<\/jats:italic> infection. Our findings suggest the involvement of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> cells producing <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 and <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 in the <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> to <jats:italic>Cryptosporidium<\/jats:italic> in naturally infected children.<\/jats:p>","DOI":"10.1111\/pim.12334","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T08:12:53Z","timestamp":1462522373000},"page":"468-480","source":"Crossref","is-referenced-by-count":1,"title":["Modulation of the immune response by infection with <i>Cryptosporidium<\/i> spp. in children with allergic diseases"],"prefix":"10.1111","volume":"38","author":[{"given":"J. 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