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These trematodes greatly affect the global agricultural community, infecting millions of ruminants worldwide and causing annual economic losses in excess of\n                    <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\n                    $3 billion. Fasciolosis, an important zoonosis, is classified by\n                    <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>\n                    as a neglected tropical disease with an estimated 17 million people infected and a further 180 million people at risk of infection. The significant impact on agriculture and human health together with the increasing demand for animal\u2010derived food products to support global population growth demonstrate that fasciolosis is a major One Health problem. This review details the problematic issues surrounding fasciolosis control, including drug resistance, lack of diagnosis and the threat that hybridization of the\n                    <jats:italic>Fasciola<\/jats:italic>\n                    species poses to future animal and human health. We discuss how these parasites may mediate their long\u2010term survival through regulation and modulation of the host immune system, by altering the host immune homeostasis and\/or by influencing the intestinal microbiome particularly in respect to concurrent infections with other pathogens. Large genome, transcriptome and proteomic data sets are now available to support an integrated One Health approach to develop novel diagnostic and control strategies for both animal and human disease.\n                  <\/jats:p>","DOI":"10.1111\/pim.12343","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T10:17:11Z","timestamp":1466158631000},"page":"558-568","source":"Crossref","is-referenced-by-count":185,"title":["A prospective view of animal and human Fasciolosis"],"prefix":"10.1111","volume":"38","author":[{"given":"K.","family":"Cwiklinski","sequence":"first","affiliation":[{"name":"School of Biological Sciences Queen's University Belfast Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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