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Multicyst infections are common in endemic countries although single\u2010cyst infection prevails in India. Single\u2010cyst infections in an endemic country suggest a role for host immunity limiting the infection. This study examined ex <jats:italic>vivo <\/jats:italic><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells and <jats:italic>in vitro<\/jats:italic> Th1 and Th2 cytokine responses to <jats:italic>T.\u00a0solium<\/jats:italic> cyst antigens of peripheral blood mononuclear cells of healthy subjects from endemic and nonendemic regions and of single\u2010 and multicyst\u2010infected patients for association with cyst burden of <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content>. <jats:italic>T.\u00a0solium<\/jats:italic> cyst antigens elicited a Th1 cytokine response in healthy subjects of <jats:italic>T.\u00a0solium<\/jats:italic>\u2010endemic and <jats:italic>T.\u00a0solium<\/jats:italic>\u2010non\u2010endemic regions and those with single\u2010cyst infections and a Th2 cytokine response from subjects with multicyst neurocysticercosis. Multicyst neurocysticercosis subjects also exhibited low levels of effector memory <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells. Th1 cytokine response of <jats:italic>T.\u00a0solium<\/jats:italic> exposure and low infectious loads may aid in limiting cyst number. Th2 cytokines and low effector T cells may enable multiple\u2010cyst infections to establish and persist.<\/jats:p>","DOI":"10.1111\/pim.12351","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T07:16:15Z","timestamp":1470381375000},"page":"628-634","source":"Crossref","is-referenced-by-count":18,"title":["Host Th1\/Th2 immune response to <i>Taenia solium<\/i> cyst antigens in relation to cyst burden of neurocysticercosis"],"prefix":"10.1111","volume":"38","author":[{"given":"J.","family":"Tharmalingam","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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