{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:52:19Z","timestamp":1783385539210,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007469","name":"Higher Education Research Promotion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Summary<\/jats:title>Opisthorchis viverrini<\/jats:italic> causes public health problems in South\u2010East Asia. Recently, TGF<\/jats:styled-content>\u2010\u03b2 and IL<\/jats:styled-content>\u201010 have been reported to increase in O. viverrini<\/jats:italic>\u2010infected hamsters but the sources of these cytokines are still unknown. In this study, the CD<\/jats:styled-content>4+<\/jats:sup> T cells in infected hamsters were investigated. It was demonstrated that IL<\/jats:styled-content>\u20104+<\/jats:sup>CD<\/jats:styled-content>4+<\/jats:sup> T cells were significantly increased in hamster spleens and mesenteric lymph nodes (MLN<\/jats:styled-content>s) during chronic infection. Interestingly, IL<\/jats:styled-content>\u201010+<\/jats:sup>CD<\/jats:styled-content>4+<\/jats:sup> T cells were also discovered at a significant level while Treg (T regulatory)\u2010like TGF<\/jats:styled-content>\u2010 \u03b2+<\/jats:sup>CD<\/jats:styled-content>4+<\/jats:sup> T cells were in MLN<\/jats:styled-content>s of infected hamsters. Moreover, the CD<\/jats:styled-content>4+<\/jats:sup>CD<\/jats:styled-content>25+<\/jats:sup>Foxp3+<\/jats:sup> Treg cell response was significantly found both in spleens and MLN<\/jats:styled-content>s in infected hamsters. The findings were then confirmed by development of T\u2010cell clones against crude somatic antigens (CSA<\/jats:styled-content>g) in immunized BALB<\/jats:styled-content>\/c mice. Five clones named TCC<\/jats:styled-content>21, TCC<\/jats:styled-content>23, TCC<\/jats:styled-content>35, TCC<\/jats:styled-content>41 and TCC<\/jats:styled-content>108 were established. The TCC<\/jats:styled-content>21 was found to be the TGF<\/jats:styled-content>\u2010\u03b2+<\/jats:sup>CD<\/jats:styled-content>4+<\/jats:sup> while TCC<\/jats:styled-content>35, TCC<\/jats:styled-content>41 and TCC<\/jats:styled-content>108 were IL<\/jats:styled-content>\u20104+<\/jats:sup>CD<\/jats:styled-content>4+<\/jats:sup> and TCC<\/jats:styled-content>23 was IFN<\/jats:styled-content>\u2010\u03b3+<\/jats:sup>CD<\/jats:styled-content>4+<\/jats:sup>. This TGF<\/jats:styled-content>\u2010\u03b2+<\/jats:sup>CD<\/jats:styled-content>4+<\/jats:sup> T clone showed an inhibitory function in vitro<\/jats:italic> in mononuclear cell proliferation via TGF<\/jats:styled-content>\u2010\u03b2\u2010mediated mechanisms. This study indicated that O. viverrini<\/jats:italic>\u2010infected hamsters could induce TGF<\/jats:styled-content>\u2010\u03b2+<\/jats:sup> CD<\/jats:styled-content>4+<\/jats:sup> Treg\u2010like cells. The CSA<\/jats:styled-content>g\u2010specific Tregs secreted high TGF<\/jats:styled-content>\u2010\u03b2, and limited immune cell proliferation.<\/jats:p>","DOI":"10.1111\/pim.12358","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T13:56:45Z","timestamp":1471960605000},"page":"688-697","source":"Crossref","is-referenced-by-count":22,"title":["Induction of regulatory T cells by Opisthorchis viverrini<\/i>"],"prefix":"10.1111","volume":"38","author":[{"given":"C.","family":"Kaewraemruaen","sequence":"first","affiliation":[{"name":"Department of Microbiology Khon Kaen University Khon Kaen Thailand"},{"name":"Melioidosis Research Center Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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