{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:58:39Z","timestamp":1772071119013,"version":"3.50.1"},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T00:00:00Z","timestamp":1484784000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>During the course of infection with<jats:italic>Trichinella spiralis<\/jats:italic>, an inflammatory response is triggered at the intestinal level in the host, playing a crucial role in the expulsion and elimination of the parasite. However, several studies have demonstrated that this inflammatory response is harmful to the host; hence, the importance of studying molecules with therapeutic potential like resiniferatoxin, which is known to have an anti\u2010inflammatory effect both in vitro and in vivo. In this article, we evaluated the anti\u2010inflammatory activity of resiniferatoxin during the intestinal phase of<jats:italic>T.\u00a0spiralis<\/jats:italic>infection by quantitatively determining the levels of TNF\u2010\u03b1, NO and PGE<jats:sub>2<\/jats:sub>as well as the percentage of eosinophils in the blood and intestinal pathology. In addition, parasite burden was determined during the muscle infection. Our results show that resiniferatoxin lowered the serum levels of TNF\u2010\u03b1, NO and PGE<jats:sub>2<\/jats:sub>, as well as the percentage of eosinophils in the blood and intestinal pathology during the intestinal infection. Moreover, resiniferatoxin also lowered the parasite burden in muscle, resulting in a reduction of the humoral response (IgG) associated to treatment with resiniferatoxin. These findings suggest a potential therapeutic use of the anti\u2010inflammatory effect of resiniferatoxin, which also contributes to host defence against the challenge of<jats:italic>T.\u00a0spiralis<\/jats:italic>infection.<\/jats:p>","DOI":"10.1111\/pim.12393","type":"journal-article","created":{"date-parts":[[2016,10,15]],"date-time":"2016-10-15T14:42:54Z","timestamp":1476542574000},"source":"Crossref","is-referenced-by-count":27,"title":["Resiniferatoxin lowers TNF\u2010\u03b1, NO and PGE<sub>2<\/sub>in the intestinal phase and the parasite burden in the muscular phase of<i>Trichinella\u00a0spiralis<\/i>infection"],"prefix":"10.1111","volume":"39","author":[{"given":"J. L.","family":"Mu\u00f1oz\u2010Carrillo","sequence":"first","affiliation":[{"name":"Laboratory of Cell Biology and Microbiology Academic Unit of Biological Sciences Autonomous University of Zacatecas Zacatecas M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Mu\u00f1oz\u2010Escobedo","sequence":"additional","affiliation":[{"name":"Academic Unit of Odontology Autonomous University of Zacatecas Zacatecas M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Maldonado\u2010Tapia","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology and Microbiology Academic Unit of Biological Sciences Autonomous University of Zacatecas Zacatecas M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Ch\u00e1vez\u2010Ruvalcaba","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology and Microbiology Academic Unit of Biological Sciences Autonomous University of Zacatecas Zacatecas M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Moreno\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology and Microbiology Academic Unit of Biological Sciences Autonomous University of Zacatecas Zacatecas M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra064142"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2012.07.009"},{"key":"e_1_2_6_4_1","first-page":"47","article-title":"Detecci\u00f3n de Trichinella spiralis en cerdos faenados en dos plantas de beneficio en el municipio de bello","volume":"4","author":"Laverde LM","year":"2009","journal-title":"Revista CES Medicina Veterinaria y Zootecnia"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.2478"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152610793180830"},{"key":"e_1_2_6_7_1","first-page":"203","article-title":"Fase Intestinal de Trichinella spiralis en modelo murino","volume":"14","author":"Moreno MA","year":"2009","journal-title":"Acta Biolo Colomb"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-1-27"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/187153012799279081"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.11.176"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8287-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2000.00328.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2007.00985.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182008004319"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v2.i5.72"},{"key":"e_1_2_6_16_1","first-page":"469","article-title":"Nitric oxide and superoxide in inflammation and immune regulation","volume":"54","author":"Guzik TJ","year":"2003","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1010550"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1128\/mr.59.4.533-547.1995","article-title":"Role of nitric oxide in parasitic infections","volume":"59","author":"James SL","year":"1995","journal-title":"Microbiol Rev"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199809)28:09<2672::AID-IMMU2672>3.0.CO;2-F"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.8.4229"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00026-08"},{"key":"e_1_2_6_22_1","first-page":"537","article-title":"The use of prednisone in the treatment of trichinellosis","volume":"9","author":"Shimoni Z","year":"2007","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_6_23_1","unstructured":"AlvaradoRM MezaLE Garc\u00edaME Sald\u00edvarS MorenoGA.Hormonal effect on the parasite load in the infection by T.\u00a0spiralis of a murine experimental model. Trichinellosis.9th International Conference Trichinellosis (ICT9). Edit. Ortega P. Wakelin 1996:107\u2013114."},{"key":"e_1_2_6_24_1","first-page":"233","article-title":"The effect of immunomodulating drugs on the percentage of apoptotic and necrotic lymphocytes in inflammatory infiltrations in the muscle tissue of mice infected with Trichinella spiralis","volume":"13","author":"Piekarska J","year":"2010","journal-title":"Pol J Vet Sci"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0031-6997(24)01403-0","article-title":"Vanilloid (Capsaicin) receptors and mechanisms","volume":"51","author":"Szallasi A","year":"1999","journal-title":"Pharmacol Rev"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161209787581995"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.113.008268"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.157.10.4412"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705533"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.31623"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31816f6884"},{"key":"e_1_2_6_32_1","first-page":"1","volume-title":"Manual of Histologic and Special Staining Techniques","author":"Armed Forces, Institute of Pathology","year":"1957"},{"issue":"5","key":"e_1_2_6_33_1","first-page":"1","article-title":"Utilidad del modelo experimental de cerdo en el estudio y tratamiento de la Trichinellosis","volume":"12","author":"Ch\u00e1vez MI","year":"2011","journal-title":"Redvet"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X99000360"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2005.05.036"},{"key":"e_1_2_6_36_1","first-page":"51","article-title":"Utilidad del albendazol\/quinfamida en el tratamiento de la fase intestinal de la infecci\u00f3n por Trichinella spiralis en modelo Murino","volume":"31","author":"Garc\u00eda MJ","year":"2012","journal-title":"Archivos Venezolanos de Farmacolog\u00eda y Terap\u00e9utica"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_6_38_1","first-page":"57","article-title":"Experimental swine trichinellosis: use of Dot_ELISA and Western Blot with excretion\/secretion antigens (ES) from infective larvae to detect anti\u2010Trichinella spiralis antibodies","volume":"42","author":"Aguilar BR","year":"2000","journal-title":"Rev Latinoam Microbiol"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-27"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq031"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2007.16"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01461-08"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.07.026"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.207449"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12731"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(00)00352-6"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.175"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2011-0068"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-11-0318"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01199.x"},{"key":"e_1_2_6_52_1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.33588\/rn.4807.2009124","article-title":"El canal TRPV1 como diana para tratar el dolor","volume":"48","author":"Salazar H","year":"2009","journal-title":"Rev Neurol"},{"key":"e_1_2_6_53_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.24.021605.090720","article-title":"The eosinophil","volume":"24","author":"Rothenberg ME","year":"2006","journal-title":"Immunology"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2008.07.001"},{"key":"e_1_2_6_55_1","first-page":"340","article-title":"Glucocorticoid\u2010induced apoptotic pathways in eosinophils: comparison with glucocorticoid\u2010sensitive leukaemia cells","volume":"71","author":"Arai Y","year":"2000","journal-title":"Int J Hematol"},{"key":"e_1_2_6_56_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4049\/jimmunol.147.1.254","article-title":"Glucocorticoids inhibit eosinophil responses to granulocyte\u2010macrophage colony\u2010stimulating factor","volume":"147","author":"Lamas AM","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.3.415"},{"key":"e_1_2_6_58_1","doi-asserted-by":"crossref","first-page":"5554","DOI":"10.4049\/jimmunol.160.11.5554","article-title":"Mast cells enhance eosinophil survival in vitro: role of TNF\u2010a and granulocyte\u2010macrophage colony stimulating factor","volume":"60","author":"Levi\u2010Schaffer F","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7961-3-5"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.3.1577"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400852"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402219"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005347"},{"key":"e_1_2_6_64_1","first-page":"59","article-title":"Influence of Trichinella spiralis infective dose on the level of antibodies, circulating antigens and circulating immune complexes in rats","volume":"37","author":"Dziemian E","year":"2000","journal-title":"Helminthologia"},{"key":"e_1_2_6_65_1","first-page":"117","article-title":"Clinical trichinellosis","volume":"4","author":"Murrell KD","year":"1994","journal-title":"Prog Clin Parasitol"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102107"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.046"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004360100420"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2005.09.004"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.2478\/s11687-010-0023-x"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12393","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T13:42:42Z","timestamp":1749649362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/pim.12393"],"URL":"https:\/\/doi.org\/10.1111\/pim.12393","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"article-number":"e12393"}}