{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T16:27:01Z","timestamp":1777998421560,"version":"3.51.4"},"reference-count":68,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["221405"],"award-info":[{"award-number":["221405"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["216344"],"award-info":[{"award-number":["216344"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Cutaneous leishmaniasis caused by <jats:italic>Leishmania mexicana<\/jats:italic> is associated with an important inflammatory response. We here analysed the kinetics of Th17 cells and neutrophils in ear lobe lesions caused by <jats:italic>Leishmania mexicana<\/jats:italic> throughout 90\u00a0days of disease progression in susceptible <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c and semi\u2010resistant C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice infected with 1\u00a0\u00d7\u00a010<jats:sup>5<\/jats:sup> <jats:italic>Leishmania mexicana<\/jats:italic> promastigotes. Cells in the lesions were extracted and quantified by flow cytometry, whereas their distribution in the tissues in relation to the parasites was analysed by immunohistochemistry. Our results show that in <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c mice, both Th17 cells and neutrophils increase concomitantly and to significantly higher levels on day 90 post\u2010infection, as compared to C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice. Our results provide novel evidence on the cells causing chronic inflammation throughout <jats:italic>Leishmania mexicana<\/jats:italic> infections, resulting as a consequence of neutrophil recruitment together with Th17 cell differentiation and recruitment, both of which remain in the infection site throughout the late phase of the infection. We conclude that the more enhanced levels of Th17 cells and neutrophils during chronic inflammatory lesions in <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c mice participate in their enhanced susceptibility towards a progressive disease evolution, whereas the more controlled response of these cells in C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice possibly relates to the more resistant profile of this mouse strain.<\/jats:p>","DOI":"10.1111\/pim.12420","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T17:04:49Z","timestamp":1487264689000},"source":"Crossref","is-referenced-by-count":32,"title":["Th17 cells and neutrophils: Close collaborators in chronic <i>Leishmania mexicana<\/i> infections leading to disease severity"],"prefix":"10.1111","volume":"39","author":[{"given":"C. P.","family":"Pedraza\u2010Zamora","sequence":"first","affiliation":[{"name":"Facultad de Medicina Unidad de Investigaci\u00f3n en Medicina Experimental Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Hospital General de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Delgado\u2010Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Unidad de Investigaci\u00f3n en Medicina Experimental Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Hospital General de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zamora\u2010Chimal","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Unidad de Investigaci\u00f3n en Medicina Experimental Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Hospital General de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-4998","authenticated-orcid":false,"given":"I.","family":"Becker","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Unidad de Investigaci\u00f3n en Medicina Experimental Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Hospital General de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization \u2010 Fact sheet 375: Leishmaniasis[homepage on the internet]. WHO; c2016 [updated September 2016].http:\/\/www.who.int\/mediacentre\/factsheets\/fs375\/en\/. Accessed May 23 2016."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2007.04.003"},{"key":"e_1_2_8_4_1","unstructured":"Flisser SteinbruchA P\u00e9rez TamayoR.Leishmaniosis (cap\u00edtulo escrito por Ingeborg Becker). En. Aprendizaje de la parasitolog\u00eda basado en problemas.1\u00aa edici\u00f3n. M\u00e9xico: Editorial Manual Moderno; 2006. P.394\u2010409."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-6-196"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/945871"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-86702007000100030"},{"key":"e_1_2_8_8_1","unstructured":"WHO Leishmaniasis in Guatemala[database in the Internet]. WHO.http:\/\/www.who.int\/leishmaniasis\/resources\/GUATEMALA.pdf. 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