{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:47:22Z","timestamp":1791859642671,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Cellular hyporesponsiveness observed during helminth infections is attributed to factors such as antigen\u2010presenting cells (<jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>) dysfunction, increased interleukin\u201010(<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010), regulatory T cells and induction of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T (Th)\u2010cell apoptosis. Increased Fas ligand (FasL) expression on the surface of B\u20101 cells and induction of apoptosis of Th cells by FasL\u2010expressing B\u20101 cells due to helminth infection were demonstrated in murine model of helminth infection where as profile of FasL expression, Th\u2010cell apoptosis and correlation between these two populations of cells in clinical filariasis remain unknown. In this study, we have scored the profile of apoptotic Th\u2010cell population and FasL\u2010expressing B\u20101 cells in different clinical categories of filariasis. The peripheral apoptotic T\u2010helper cells were significantly increased in filarial patients compared to endemic controls. Expression of FasL on the surface of peripheral B\u20101 cells increased in filarial patients and positively correlated with peripheral apoptotic T\u2010helper cells indicating FasL\u2010expressing B\u20101 cells may be one of the important mediators of Th\u2010cell apoptosis and immune anergy during filarial pathology.<\/jats:p>","DOI":"10.1111\/pim.12421","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:36:41Z","timestamp":1487291801000},"source":"Crossref","is-referenced-by-count":17,"title":["Increased Fas ligand expression of peripheral B\u20101 cells correlated with <scp>CD<\/scp>4<sup>+<\/sup> T\u2010cell apoptosis in filarial\u2010infected patients"],"prefix":"10.1111","volume":"39","author":[{"given":"R.","family":"Mishra","sequence":"first","affiliation":[{"name":"Regional Medical Research Centre (ICMR)  Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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